MABS481

Anti-PL Scramblase 3, clone 3B4 Antibody

clone 3B4, from mouse

• 别名: Phospholipid scramblase 3, PL scramblase 3, Ca(2+)-dependent phospholipid scramblase 3
• UNSPSC代码: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物来源: mouse
• 质量水平: 100
• 抗体形式: purified immunoglobulin
• 抗体产品类型: primary antibodies
• 克隆: 3B4, monoclonal
• 种属反应性: human, mouse
• 技术: western blot: suitable
• 同位素/亚型: IgG1κ
• NCBI登记号: NP_001161969
• UniProt登记号: Q9JIZ9
• 运输: wet ice
• 靶向翻译后修饰: unmodified
• 基因信息: human ... PLSCR3(57048)

说明

一般描述

Phospholipid scramblase 3 (PL scramblase 3), also known as Ca(2+)-dependent phospholipid scramblase 3, and encoded by the gene name PLSCR3, is a member of the phospholipid scramblase family. Recent studies have indicated that PL scramblase 3 may mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. PL scramblase 3 is suggested to play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. It may also play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages. PL scramblase 3 has been demonstrated to interact with PDCD6 in a calcium-dependent manner.

免疫原

Recombinant protein corresponding to human PL Scramlase 3.

应用

This Anti-PL Scramblase 3 antibody is validated for use in Western Blotting for the detection of PL Scramblase 3.

Western Blotting Analysis: A representative lot detected PL Scramlase 3 in SH-SY5Y cell lysate (Chu, C.T., et al. (2013). Nature Cell Biology. 15(10):1197-1205).
Western Blotting Analysis: A representative lot detected PL Scramlase 3 in primary adipocytes lysate (Wiedmer, T., et al. (2004). PNAS. 101(36):13296-13301).

质量

Evaluated by Western Blotting in NIH-3T3/L1 cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected PL Scramlase 3 in 10 µg of NIH-3T3/L1 cell lysate.

目标描述

~31 kDa observed

外形

Format: Purified

其他说明

Concentration: Please refer to lot specific datasheet.

安全信息

• 储存分类代码: 12 - Non Combustible Liquids
• WGK: WGK 1