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生物源
mouse
品質等級
共軛
unconjugated
抗體表格
purified antibody
抗體產品種類
primary antibodies
無性繁殖
P2A12, monoclonal
分子量
calculated mol wt 45.21 kDa
observed mol wt ~17 kDa
純化經由
using protein G
物種活性
human
包裝
antibody small pack of 100 μg
技術
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable
同型
IgG1κ
表位序列
N-terminal half
Protein ID登錄號
UniProt登錄號
運輸包裝
2-8°C
目標翻譯後修改
unmodified
基因資訊
mouse ... HP(3240)
一般說明
Haptoglobin (UniProt: P00738; also known as Zonulin) is encoded by the HP gene (Gene ID: 3240) in human. Haptoglobin is a hemoglobin-binding acute-phase glycoprotein that is synthesized in the liver and is secreted in plasma. Although it belongs to the peptidase S1 family, it does not have any enzymatic activity. It is a tetramer of disulfide-linked two alpha and two beta chains and displays anti-inflammatory and antioxidative properties. It is synthesized with a signal peptide (aa 1-18), which is subsequently cleaved off to generate the mature form that can be further cleaved into an alpha (19-160) and a beta chain (aa 162-406). Haptoglobin complexes with free hemoglobin, resulting from erythrocyte hemolysis, and allows hepatic recycling of heme iron and prevents kidney damage. Hemoglobin/haptoglobin complex is rapidly cleared by the macrophage CD163 scavenger receptor expressed on Kupfer cells through an endocytic lysosomal degradation pathway. Its CD163 interacting region is localized to amino acids 318-323. (Ref.: Schaer, DJ., et al. (2014). Front. Physiol. 5; 415).
特異性
Clone P2A12 is a mouse monoclonal antibody that detects human Haptoglobin. It targets an epitope within the alpha-2 chain.
免疫原
Mixed type Haptoglobin from human plasma.
應用
Quality Control Testing
Evaluated by Western Blotting with purified human haptoglobin plasma.
Western Blotting Analysis (WB): A 1:1,000 dilution of this antibody detected purified Haptoglobin from human plasma.
Tested Applications
Immunohistochemistry (Paraffin) Analysis: A 1:250 dilution of this antibody detected Haptoglobin in human liver tissue sections.
Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user
Evaluated by Western Blotting with purified human haptoglobin plasma.
Western Blotting Analysis (WB): A 1:1,000 dilution of this antibody detected purified Haptoglobin from human plasma.
Tested Applications
Immunohistochemistry (Paraffin) Analysis: A 1:250 dilution of this antibody detected Haptoglobin in human liver tissue sections.
Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user
Anti-Haptoglobin, clone P2A12, Cat. No. MABS2242, is a mouse monoclonal antibody that detects Haptoglobin and is tested for use in Immunohistochemistry (Paraffin) and Western Blotting.
外觀
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
儲存和穩定性
Recommend storage at +2°C to +8°C. For long term storage antibodies can be kept at -20°C. Avoid repeated freeze-thaws.
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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