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生物源
mouse
品質等級
抗體表格
purified antibody
抗體產品種類
primary antibodies
無性繁殖
3D9, monoclonal
物種活性
rat
物種活性（以同源性預測）
human (immunogen homology)
技術
immunocytochemistry: suitable
western blot: suitable
同型
IgMκ
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... DRD2(1813)
rat ... Drd2(24318)
一般說明
中枢神经系统多巴胺能系统的问题被认为是某些神经精神疾病的根本原因。多巴胺D2受体是多巴胺的五种类型（D1至D5）受体之一。该受体的活性由抑制腺苷酸环化酶的G蛋白介导。使用Nurr1和ERK的多巴胺D2受体信号传导可能在中脑多巴胺能神经元发育中起重要作用。有缺陷的D2受体在ROS依赖性高血压病例中很常见。此外，DRD2的缺陷与酒精反应性肌张力障碍，对家族性酒精中毒的易感性不同以及酗酒者自杀风险的促成因素有关。
免疫原
对应于人多巴胺D2受体的线性肽。
應用
免疫细胞化学分析：独立实验室使用了一个先前批次来检测Ntera-2细胞和大鼠脑神经元中的多巴胺D2受体。 由Wolfson Centre for Inherited Neuromuscular Disease的Glenn Morris提供。
经验证，该抗多巴胺D2受体（DRD2）抗体（克隆2B9）可用于检测多巴胺D2受体（DRD2）的WB、IC。
品質
通过蛋白质印迹法在大鼠脊髓组织裂解物中进行评估。
蛋白质印迹分析：5 µg/mL的该抗体在10 µg大鼠脊髓组织裂解物上检测到多巴胺D2受体。
蛋白质印迹分析：5 µg/mL的该抗体在10 µg大鼠脊髓组织裂解物上检测到多巴胺D2受体。
標靶描述
观测分子量〜50 kDa
外觀
形式：纯化
分析報告
对照
大鼠脊髓组织裂解物
大鼠脊髓组织裂解物
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Dasiel O Borroto-Escuela et al.
Frontiers in molecular neuroscience, 16, 1106765-1106765 (2023-06-09)
Previous studies have indicated that acute treatment with the monoamine stabilizer OSU-6162 (5 mg/kg), which has a high affinity for Sigma1R, significantly increased the density of accumbal shell D2R-Sigma1R and A2AR-D2R heteroreceptor complexes following cocaine self-administration. Ex vivo studies using
Wilber Romero-Fernandez et al.
Molecular neurobiology, 59(10), 5955-5969 (2022-07-14)
The adenosine A2A receptor (A2AR), dopamine D2 receptor (D2R) and metabotropic glutamate receptor type 5 (mGluR5) form A2AR-D2R-mGluR5 heteroreceptor complexes in living cells and in rat striatal neurons. In the current study, we present experimental data supporting the view that
Dasiel O Borroto-Escuela et al.
International journal of molecular sciences, 20(23) (2019-12-11)
It was previously demonstrated that rat adenosine A2AR transmembrane V peptide administration into the nucleus accumbens enhances cocaine self-administration through disruption of the A2AR-dopamine (D2R) heteroreceptor complex of this region. Unlike human A2AR transmembrane 4 (TM4) and 5 (TM5), A2AR
Dasiel O Borroto-Escuela et al.
Frontiers in pharmacology, 9, 829-829 (2018-09-15)
The A2A adenosine (A2AR) and D2 dopamine (D2R) receptors form oligomers in the cell membrane and allosteric interactions across the A2AR-D2R heteromer represent a target for development of drugs against central nervous system disorders. However, understanding of the molecular determinants
Dasiel O Borroto-Escuela et al.
Neurotoxicity research, 37(2), 433-444 (2019-11-30)
Cocaine was previously shown to act at the Sigma1R which is a target for counteracting cocaine actions. It therefore becomes of interest to test if the monoamine stabilizer (-) OSU-6162 (OSU-6162) with a nanomolar affinity for the Sigma1R can acutely
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