MABC545
Anti-FANCM Antibody, clone CV5.1
clone CV5.1, 0.5 mg/mL, from mouse
别名:
Fanconi anemia group M protein, Protein FACM, ATP-dependent RNA helicase FANCM, Fanconi anemia-associated polypeptide of 250 kDa, FAAP250, Protein Hef ortholog
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所有图片(1)
About This Item
分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41
推荐产品
生物源
mouse
品質等級
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
CV5.1, monoclonal
物種活性
human
濃度
0.5 mg/mL
技術
immunocytochemistry: suitable
同型
IgG1κ
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... FANCM(57697)
一般說明
FANCM, also known as Fanconi anemia group M protein (FACM), or ATP-dependent RNA helicase FANCM, or Fanconi anemia-associated polypeptide of 250 kDa (FAAP250), or Protein Hef ortholog, and encoded by the gene FANCM/KIAA1596,is a critical ATPase needed for proper DNA repair. FANCM is found at DNA replication forks and required for cellular resistance to DNA cross-linking agents and for proper DNA repair. FANCM belongs to a multi-subunit FA (Fanconi anemia) complex. FANCM is localized to the nucleus and expressed in most cells. Defects in FANCM may be associated with Fanconi anemia complementation group M (FANCM) a disorder affecting hematopoietic cells can causing anemia, leukopenia and thrombopenia. Patients also have cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition toward malignancies. Patient’s cells show hypersensitivity to DNA-damaging agents, chromosomal instability and defective DNA repair.
免疫原
His-tagged recombinant protein corresponding to human FANCM.
應用
Detect FANCM using this Anti-FANCM Antibody, clone CV5.1 validated for use in ICC.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Apoptosis - Additional
Apoptosis - Additional
品質
Evaluated by Immunohistochemistry Analysis in A431, HeLa, and HepG2 cells.
Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected FANCM in A431, HeLa, and HepG2 cells.
Dylight® is a registered trademark of Thermo Fisher Scientific.
Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected FANCM in A431, HeLa, and HepG2 cells.
Dylight® is a registered trademark of Thermo Fisher Scientific.
標靶描述
230 kDa calculated
外觀
Protein G Purified
Format: Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
儲存和穩定性
Stable for 1 year at 2-8°C from date of receipt.
法律資訊
DyLight is a registered trademark of Pierce Biotechnology, Inc.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Massimo Bogliolo et al.
Genetics in medicine : official journal of the American College of Medical Genetics, 20(4), 458-463 (2017-08-25)
PurposeMutations in genes involved in Fanconi anemia (FA)/BRCA DNA repair pathway cause cancer susceptibility diseases including familial breast cancer and Fanconi anemia (FA). A single FA patient with biallelic FANCM mutations was reported in 2005 but concurrent FANCA pathogenic mutations
Gisella Figlioli et al.
NPJ breast cancer, 5, 38-38 (2019-11-09)
Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been
Chia-Yu Guh et al.
Nature communications, 13(1), 5781-5781 (2022-10-03)
Alternative Lengthening of Telomeres (ALT) utilizes a recombination mechanism and break-induced DNA synthesis to maintain telomere length without telomerase, but it is unclear how cells initiate ALT. TERRA, telomeric repeat-containing RNA, forms RNA:DNA hybrids (R-loops) at ALT telomeres. We show
Neus P Lorite et al.
Cellular and molecular life sciences : CMLS, 81(1), 251-251 (2024-06-07)
The Smc5/6 complex is a highly conserved molecular machine involved in the maintenance of genome integrity. While its functions largely depend on restraining the fork remodeling activity of Mph1 in yeast, the presence of an analogous Smc5/6-FANCM regulation in humans
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