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HMMP2MAG-55K

MILLIPLEX^® 人MMP磁珠板2-免疫学多重检测

Name: MILLIPLEX<SUP>®</SUP> 人MMP磁珠板2-免疫学多重检测
Brand: MM

Matrix Metalloproteinase Bead-Based Multiplex Assays using the Luminex technology enable the simultaneous analysis of multiple MMPs biomarkers in human serum, plasma and cell culture samples.

别名:

Human matrix metalloproteinase multiplex kit, Luminex^® Human MMP immunoassay, Millipore human MMP panel

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About This Item

分類程式碼代碼:

12161503

eCl@ss:

32161000

NACRES:

NA.84

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品質等級

200

物種活性

human

製造商／商標名

Milliplex^®

assay range

accuracy: 72-98%
standard curve range: 14-10,000 pg/mL
(MMP-9)
standard curve range: 27-20,000 pg/mL
(MMP-1)
standard curve range: 27-20,000 pg/mL
(MMP-10)
standard curve range: 548-400,000 pg/mL
(MMP-7)
standard curve range: 68-50,000 pg/mL
(MMP-2)

技術

multiplexing: suitable

檢測方法

fluorometric (Luminex xMAP)

運輸包裝

wet ice

一般說明

基质金属蛋白酶（MMPs）是一种锌蛋白酶家族，负责细胞外基质（ECM）的分解，在正常的生理过程中起着关键作用，例如胚胎发育和组织形态发生、组织和骨骼重塑、伤口愈合和血管生成。这些过程依赖于MMPs在细胞表面受体的裂解，凋亡配体的释放，细胞增殖和分化以及趋化因子活性调节中的作用。在结构上相似，MMP作为无活性原酶合成并分泌，需要蛋白水解裂解才能激活。该过程可以由丝氨酸蛋白酶或其他MMP介导。MMP表达的增加是对多种刺激（包括粘连分子，生长因子，细胞因子和激素）的响应而发生的。MMP活性的调节主要由TIMP（金属蛋白酶的组织抑制剂）控制。因此，MMP/TIMP平衡的破坏可导致关节炎、心血管疾病和肿瘤生长以及转移。
MMP/TIMP研究对于更深入地了解慢性炎症、心血管疾病和癌症等疾病状态发挥重要作用。

MILLIPLEX^® 人MMP珠面板2（MMP-1，-2，-7，-9，-10）将使您能够探索多个治疗领域中MMP表达的调节和功能。

Luminex^® xMAP^®平台使用磁珠免疫分析格式，以实现理想的速度和灵敏度，同时定量多种分析物，从而显著提高生产力，同时节省宝贵的样本量。

面板类型：细胞因子/趋化因子

特異性

交叉反应性
在该面板的分析物之间未观察到显著的交叉反应性。

應用

分析物：MMP-1，MMP-2，MMP-7，MMP-9，MMP-10
推荐的样品类型：人血清，血浆，组织/细胞裂解液和培养上清液样品
推荐的样品稀释度：1:20
分析运行时间：一天
研究类别：炎症 & 免疫学

特點和優勢

通过在此面板中选择可用的分析物来设计多重试剂盒。

儲存和穩定性

试剂盒组分建议的存储温度为2-8°C。

其他說明

灵敏度：单个分析物的灵敏度见方案。

法律資訊

Luminex is a registered trademark of Luminex Corp

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

象形圖

GHS08,GHS05,GHS07,GHS09

訊號詞

Danger

危險聲明

H302 + H312 + H332,H317,H318,H373,H411

防範說明

P273 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P314

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

標靶器官

Respiratory Tract

儲存類別代碼

10 - Combustible liquids

分析证书(COA)

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Association between MMP/TIMP Levels in the Aqueous Humor and Plasma with Axial Lengths in Myopia Patients.

Yu Yue et al.

BioMed research international, 2020, 2961742-2961742 (2020-07-01)

The present study investigated the profiles of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) of the aqueous humor (AH) and plasma (PL) in myopia patients, to determine whether there was an association between these levels with their axial

Changes of Proteases, Antiproteases, and Pathogens in Cystic Fibrosis Patients' Upper and Lower Airways after IV-Antibiotic Therapy.

Ulrike Müller et al.

Mediators of inflammation, 2015, 626530-626530 (2015-07-18)

In cystic fibrosis (CF) the upper (UAW) and lower airways (LAW) are reservoirs for pathogens like Pseudomonas aeruginosa. The consecutive hosts' release of proteolytic enzymes contributes to inflammation and progressive pulmonary destruction. Objectives were to assess dynamics of protease :

Physical activity intervention improved the number and functionality of endothelial progenitor cells in low birth weight children.

Livia V Souza et al.

Nutrition, metabolism, and cardiovascular diseases : NMCD, 30(1), 60-70 (2019-11-23)

The purpose of this study was to investigate whether an intervention with physical activity (PA) would promote positive effects on the angiogenic factors, mobilization, and functionality of circulating endothelial progenitor cells (EPCs) in children with low birth weight (LBW). Thirty-five

Blood-Based Biomarkers Predictive of Metformin Target Engagement in Fragile X Syndrome.

Mittal Jasoliya et al.

Brain sciences, 10(6) (2020-06-14)

Recent advances in neurobiology have provided several molecular entrees for targeted treatments for Fragile X syndrome (FXS). However, the efficacy of these treatments has been demonstrated mainly in animal models and has not been consistently predictive of targeted drugs' response

Semen levels of matrix metalloproteinase (MMP) and tissue inhibitor of metallorproteinases (TIMP) protein families members in men with high and low sperm DNA fragmentation.

Larissa Berloffa Belardin et al.

Scientific reports, 9(1), 903-903 (2019-01-31)

Matrix Metalloproteinases (MMPs) and their regulators - Tissue Inhibitors of Matrix Metalloproteinases (TIMPs) - participate in extracellular matrix remodeling, fibrosis, and semen liquefaction, as well as to inflammatory activity. Seminal plasma has been shown to contain MMPs (MMP-2 and MMP-9)

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MILLIPLEX^® 人MMP磁珠板2-免疫学多重检测