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Merck
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Key Documents

FCABS400F

Sigma-Aldrich

Milli-Mark® 抗-FcεRI抗体，γ 亚基-FITC

Milli-Mark®, from rabbit

别名:

Fc fragment of IgE high affinity I receptor for gamma polypeptide, Fc-epsilon RI-gamma, FceRI gamma, IgE Fc receptor subunit gamma, Immunoglobulin E receptor, high affinity,gamma chain

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rabbit

品質等級

100

共軛

FITC conjugate

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

polyclonal

物種活性

mouse, human, rat

製造商／商標名

Milli-Mark®

技術

flow cytometry: suitable

同型

IgG

NCBI登錄號

NP_004097

UniProt登錄號

P30273

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... FCER1G(2207)

相关类别

一般說明

I型过敏反应是通过IgE高亲和受体（FceRI）介导的。当呈递多价抗原时，单体IgE FceRI受体复合物的重新分布会导致肥大细胞和嗜碱性粒细胞脱粒，从而导致随后释放引起I型过敏反应的因子。FceRI受体是四聚体复合物，由a链，b链和二聚体g链组成。尽管a链主要参与IgE的结合，但信号通过g亚基转移，g亚基包含免疫受体酪氨酸激活基序（ITAM），对于通过Syk和Lyn酪氨酸激酶启动受体介导的信号转导至关重要。FceRI受体能够与IgE结合和脱离，为研究激酶偶联受体的性能提供了通用模型。

特異性

可识别并特异于FcεRI，γ-亚基。

免疫原

与Fc受体γ亚基的80-86氨基酸对应的合成肽。

應用

Milli-Mark 抗-FcεRI抗体，γ亚基-FITC是针对FcεRI的抗体，用于FC。
研究子类别
炎症 & 自身免疫机制
研究类别
炎症 & 免疫学

品質

通过流式细胞术对RBL细胞进行了评估

標靶描述

计算值为10 kDa

外觀

在含0.1％叠氮化钠和15 mg/mL BSA的PBS中与FITC偶联的纯化的兔多克隆IgG。
纯化的蛋白 A

儲存和穩定性

自收到之日起，未稀释等分试样避光冷藏于 2-8°C，可保存6个月。

分析報告

对照
RBL细胞

其他說明

已证明非偶联抗体（目录编号06-727）对人和小鼠有效。
最佳工作稀释度必须由其它仪器的最终用户进行确定。

法律資訊

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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Ralf Grutza et al.
Journal of immunology (Baltimore, Md. : 1950), 204(11), 2910-2917 (2020-04-15)
Infection with the human CMV associates with phenotypic alterations in lymphocyte subsets. A highly reproducible finding in CMV-seropositive individuals is an expansion of NKG2Cpos NK cells. In this study, we analyzed if the altered NK cell compartment in CMV-seropositive human
Carmen Gómez-Escolar et al.
EMBO reports, 23(12), e55000-e55000 (2022-10-08)
Germinal centers (GC) are microstructures where B cells that have been activated by antigen can improve the affinity of their B cell receptors and differentiate into memory B cells (MBCs) or antibody-secreting plasma cells. Here, we have addressed the role
Spandan V Shah et al.
Cell reports, 25(10), 2766-2774 (2018-12-06)
Despite burgeoning evidence demonstrating the adaptive properties of natural killer (NK) cells, mechanistic data explaining these phenomena are lacking. Following antibody sensitization, NK cells lacking the Fc receptor (FcR) signaling chain (Δg) acquire adaptive features, including robust proliferation, multifunctionality, rapid
Marc Potempa et al.
Journal of immunology (Baltimore, Md. : 1950), 208(7), 1742-1754 (2022-03-25)
Although interactions between inhibitory Ly49 receptors and their self-MHC class I ligands in C57BL/6 mice are known to limit NK cell proliferation during mouse CMV (MCMV) infection, we created a 36-marker mass cytometry (CyTOF) panel to investigate how these inhibitory
Elena Woods et al.
NPJ vaccines, 6(1), 117-117 (2021-09-30)
Effective vaccines for human immunodeficiency virus-1 (HIV-1) and hepatitis C virus (HCV) remain a significant challenge for these infectious diseases. Given that the innate immune response is key to controlling the scale and nature of developing adaptive immune responses, targeting
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