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一般說明
Decapping and exoribonuclease protein (DOM3Z), also known as DXO, Dom-3 homolog Z, and encoded by the gene symbol DOM3Z/ DOM3L/ NG6, is a ribonuclease that specifically degrades pre-mRNAs with a defective 5′ end cap. DOM3Z is part of a pre-mRNA capping quality control and has decapping, pyrophosphohydrolase and 5′-3′ exonuclease activities. DOM3Z has a decapping activity toward incomplete 5′ end cap mRNAs (such as unmethylated 5′ end-capped RNA), which in return releases GpppN and 5′ end monophosphate RNA. The 5′ end monophosphate RNA is then degraded by the 5′-3′ exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Additionally, DOM3Z has been implied to have RNA 5′-pyrophosphohydrolase activity and to release pyrophosphates by hydrolyzing the 5′ end triphosphate. DOM3Z is located in the nucleus, and expressed ubiquitously.
免疫原
KLH-conjugated linear peptide corresponding to human DOM3Z.
應用
Anti-DOM3Z is an antibody against DOM3Z for use in Western Blotting.
品質
Evaluated by Western Blotting in human pancreas tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected DOM3Z in 10 µg of human pancreas tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected DOM3Z in 10 µg of human pancreas tissue lysate.
標靶描述
~45 kDa observed
其他說明
Concentration: Please refer to lot specific datasheet.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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