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品質等級
化驗
≥98% (HPLC)
形狀
liquid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
desiccated (hygroscopic)
protect from light
運輸包裝
wet ice
儲存溫度
−70°C
一般說明
表皮生长因子受体激酶自身磷酸化的有效抑制剂（IC50=100nm）。Jak家族酪氨酸激酶抑制剂。AG 490对Jak2的抑制通过诱导程序性细胞死亡，选择性地阻断体外和体内白血病细胞生长，对正常造血没有有害影响。抑制STAT-3和IL-2诱导的MF肿瘤细胞生长的组成性激活。AG 490也被证明能抑制JAK3的自激酶活性。据报道，还抑制鸟苷酸环化酶。
包裝
用惰性气体包装
警告
毒性：刺激性（B）
外觀
100 mM (5 mg/170 µl)AG490的DMSO溶液（目录号658401）。
重構
初次解冻后，分装冻存（-70°C）。一旦打开，贮备溶液在-70°C下可稳定保存6个月。
其他說明
Jaleel, M., et al. 2004.Biochemistry43, 8247.
Eriksen, K.W., et al. 2001.Leukemia15, 787.
Kirken, R.A., et al. 1999.Leukoc.Biol.65, 891.
Nielsen, M., et al. 1997.Proc.Natl.Acad.Sci. USA 94, 6764.
Meydan, N., et al. 1996.Nature 379, 645.
Gazit, A., et al. 1991.J. Med. Chem.34, 1896.
Levitzki, A. 1990.Biochem.Pharmacol.40, 913.
Eriksen, K.W., et al. 2001.Leukemia15, 787.
Kirken, R.A., et al. 1999.Leukoc.Biol.65, 891.
Nielsen, M., et al. 1997.Proc.Natl.Acad.Sci. USA 94, 6764.
Meydan, N., et al. 1996.Nature 379, 645.
Gazit, A., et al. 1991.J. Med. Chem.34, 1896.
Levitzki, A. 1990.Biochem.Pharmacol.40, 913.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
188.6 °F - closed cup - (Dimethylsulfoxide)
閃點（°C）
87 °C - closed cup - (Dimethylsulfoxide)
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