5.34360

Autophagy Inhibitor VII

• 别名: Autophagy Inhibitor VII, 6-Chloro-N-(1-ethylpiperidin-4-yl)-1,2,3,4-tetrahydroacridin-9-amine, Acridinamine 33, Tetrahydroacridine 33, THA33
• 经验公式（希尔记法）: C₂₀H₂₆ClN₃
• 分子量: 343.89
• UNSPSC代码: 12352200
• NACRES: NA.77

属性

• 方案: ≥98% (HPLC)
• 质量水平: 100
• 表单: solid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; desiccated (hygroscopic); protect from light
• 颜色: white to pale yellow
• 溶解性: DMSO: 1.6 mg/mL; water: 50 mg/mL
• 储存温度: −20°C

说明

一般描述

A cell-permeable tetrahydroacridinamine (THA) derived compound that potently suppresses autophagy (EC = 250 nM) with reduced toxicity (LD₅₀ = 27 µM) in U2OS cells. Shown to induce lysosome deacidification and increase LC3-II protein accumulation. Displays attractive biophysical properties.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

生化/生理作用

Cell permeable: yes

Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

外形

Supplied as HCl salt.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Wang, T., et al. 2015. J. Med. Chem.58, 3025.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable