481412
NF-kB Activation Inhibitor IV
The NF-kB Activation Inhibitor IV, also referenced under CAS 139141-12-1, controls the biological activity of NF-kB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
别名:
NF-kB Activation Inhibitor IV, (E)-2-Fluoro-4ʹ-methoxystilbene
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About This Item
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质量水平
方案
≥98% (HPLC)
表单
crystalline solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
溶解性
DMSO: 20 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
Fc1c(cccc1)\C=C\c2ccc(cc2)OC
InChI key
ILVFNAZMSMNXJG-RMKNXTFCSA-N
一般描述
A cell-permeable trans-stilbene Resveratrol (Cat. No. 554325) analog that exhibits much enhanced anti-inflammatory potency, but no anti-oxidant activity. Suppresses LPS-induced COX-2 mRNA expression in BV-2 cells (~46% inhibition at 150 nM) and Shown to be ~130-fold more potent than Resveratrol in inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells (IC50 = 150 nM).
生化/生理作用
Cell permeable: yes
Primary Target
NF-κB Activation
NF-κB Activation
Product does not compete with ATP.
Reversible: no
Target IC50: 150 nM inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells.
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Heynekamp, J.J., et al. 2006. J. Med. Chem.49, 7182.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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