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444295

Sigma-Aldrich

MT1-MMP Inhibitor, NSC405020

The MT1-MMP Inhibitor, NSC405020 controls the biological activity of MT1-MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

别名:

MT1-MMP Inhibitor, NSC405020, 3,4-Dichloro-N-(pentan-2-yl)benzamide, 3,4-Dichloro-N-(1-methylbutyl)benzamide

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About This Item

经验公式（希尔记法）:
C12H15Cl2NO
CAS号:
7497-07-6
分子量:
260.16
MDL编号:
MFCD02006898
UNSPSC代码:
12352200
NACRES:
NA.28

质量水平

100

方案

≥98% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

off-white

溶解性

DMSO: 100 mg/mL

运输

ambient

储存温度

2-8°C

SMILES字符串

ClC1=C(Cl)C=C(C(NC(C)CCC)=O)C=C1

InChI key

ARDYECYBETXQFD-UHFFFAOYSA-N

一般描述

A cell-permeable pentanylbenzamide compound that acts as an allosteric, reversible, and selective inhibitor of the collgenolytic activity of MT1-MMP. Does not affect the catalytic activity of cellular MT-1-MMP thus allows it to retain its ability to activate MMP-2. Selectively targets the hemopexin (PEX) domain of MT1-MMP, thereby repressing its pro-tumorigenic activity. Its binding to the PEX domain is dependent on Met-328, Arg-330, Asp-376, Met-422, and Ser-470 in the druggable pocket of the enzyme. Shown to block 184B5-MT cell migration on collagen-1 and repress MCF7-β3/MT tumor growth in xenografted mice (0.5 mg/kg, intratumoral).

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.

其他说明

Remacle, A.G., et al. 2012. Cancer Res.72, 2339.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Andrés Alberro-Brage et al.
Frontiers in immunology, 14, 1260973-1260973 (2023-09-20)
Acute respiratory distress syndrome (ARDS) is a common complication of influenza virus (IV) infection. During ARDS, alveolar protein concentrations often reach 40-90% of plasma levels, causing severe impairment of gas exchange and promoting deleterious alveolar remodeling. Protein clearance from the
Cyril Andrieu et al.
Development (Cambridge, England), 147(7) (2020-04-14)
Matrix metalloproteinases have a broad spectrum of substrates ranging from extracellular matrix components and adhesion molecules to chemokines and growth factors. Despite being mostly secreted, MMPs have been detected in the cytosol, the mitochondria or the nucleus. Although most of

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