444264

MMP Inhibitor III

The MMP Inhibitor III, also referenced under CAS 927827-98-3, controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 别名: MMP Inhibitor III
• 经验公式（希尔记法）: C₁₉H₂₉N₃O₄
• CAS号: 927827-98-3
• 分子量: 363.45
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥90% (TLC)
• 形狀: lyophilized solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated
• 顏色: off-white
• 溶解度: DMSO: 5 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C

说明

一般說明

A homophenylalanine-hydroxamic acid based broad-spectrum cell-permeable, reversible inhibitor of matrix metalloproteinases (supplied as a racemic mixture). Inhibits MMP-1 (IC₅₀ = 7.4 nM), MMP-2 (IC₅₀ = 2.3 nM), MMP-3 (IC₅₀ = 135 nM), MMP-7 (IC₅₀ = 10-100 nM), and MMP-13 (IC₅₀ = 1-10 nM).

生化／生理作用

Cell permeable: yes

Primary Target
MMP-1

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 7.4 nM, 2.3 nM, 135 nM, 10-100 nM, 1-10 nM, against MMP-1, MMP-2, MMP-3, MMP-7, and MMP-13, respectively

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months (-20°C).

其他說明

Covington, M.D., et al. 2006, Am. J. Physiol. Renal. Physiol.290, F43.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable