444251-M

MMP-2/MMP-9 Inhibitor III

The MMP-2/MMP-9 Inhibitor III controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 别名: MMP-2/MMP-9 Inhibitor III
• 经验公式（希尔记法）: C₅₂H₇₁N₁₃O₁₄S₂
• 分子量: 1166.33
• UNSPSC代码: 12352200

属性

• 质量水平: 100
• 方案: ≥97% (HPLC)
• 表单: lyophilized solid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; desiccated (hygroscopic)
• 颜色: white
• 溶解性: water: 5 mg/mL
• 储存温度: −20°C

说明

一般描述

A cyclic peptide that acts as a potent inhibitor of MMP-2 (gelatinase A; IC₅₀ = 10 µM) and MMP-9 (gelatinase B; IC₅₀ = 10 µM). Inhibits the migration of human endothelial cells and tumor cells, and prevents tumor growth and invasion in animal models.

A hydrophobic cyclic peptide that acts as a potent inhibitor of MMP-2 and MMP-9 (IC₅₀ = 10 µM). Inhibits the migration of human endothelial cells and tumor cells, and prevents tumor growth and invasion in animal models. Also, phage that display this peptide specifically targets angiogenic blood vessels in vivo.

生化/生理作用

Target IC₅₀: 10 µM against MMP-2 and MMP-9

警告

Toxicity: Standard Handling (A)

序列

H-Cys¹-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys¹⁰-OH (cyclic: 1→ 10)

其他说明

Medina, O.P., et al. 2001. Cancer Res.61, 3978.
Koivunen, E., et al. 1999. Nat. Biotechnology 17, 768.

法律信息

Sold under license of U.S. Patent 6,624,144.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 1
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable