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Merck
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Key Documents

422686

Sigma-Aldrich

Kininogen, High Molecular Weight, Single Chain, Human Plasma

Native, single chain, high molecular weight Kininogen from human plasma.

别名:

High molecular weight kininogen

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About This Item

分類程式碼代碼:
12352202
NACRES:
NA.28

品質等級

化驗

≥95% (SDS-PAGE)

形狀

liquid

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
avoid repeated freeze/thaw cycles

運輸包裝

wet ice

儲存溫度

−70°C

一般說明

Native, single chain, high molecular weight Kininogen from human plasma. Non-enzymatic cofactor of the contact activation system. Links prekallikrein to negatively charged surfaces, thereby allowing activation to kallikrein by surface-bound Factor a-XIIa. Also circulates in plasma in complex with Factor XI, that may play a role in the activation of Factor XI to Factor XIa by Factor α-XIIa. Serves as a source of bradykinin, a potent vasoactive peptide important in hypotension studies.
Native, single chain, high molecular weight Kininogen from human plasma. Nonenzymatic cofactor of the contact activation system. Links prekallikrein to negatively charged surfaces, thereby allowing activation to kallikrein by surface-bound Factor α-XIIa. Also circulates in plasma in complex with Factor XI and may play a role in the activation of Factor XI to Factor XIa by Factor α-XIIa. Serves as a source of bradykinin, a potent vasoactive peptide important in hypotension studies.

包裝

Please refer to vial label for lot-specific concentration.

警告

Toxicity: Standard Handling (A)

外觀

In 150 mM NaCl, 4 mM sodium acetate buffer, pH 5.3.

準備報告

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

重構

Following initial thaw, aliquot and freeze (-70°C).

其他說明

Weisel, J.W., et al. 1994. J. Biol. Chem. 269, 10100.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Rasmus Pihl et al.
Science advances, 7(2) (2021-02-02)
Inter-α-inhibitor heavy chain 4 (ITIH4) is a poorly characterized plasma protein that is proteolytically processed in multiple pathological conditions. However, no biological function of ITIH4 has been identified. Here, we show that ITIH4 is cleaved by several human proteases within

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