推荐产品
品質等級
化驗
≥98% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
desiccated (hygroscopic)
protect from light
顏色
off-white to yellow
溶解度
water: 2.5 mg/mL
DMSO: 5 mg/mL
運輸包裝
ambient
儲存溫度
10-30°C
InChI
1S/C6H8ClN7O.ClH/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;/h(H4,8,9,13)(H4,10,11,14,15);1H
InChI 密鑰
ACHKKGDWZVCSNH-UHFFFAOYSA-N
一般說明
血管生成抑制剂。在低浓度下，可作为跨膜Na+进入和Na+/H+ATPase的有效和特异性抑制剂。抑制平滑肌对收缩刺激的反应。阻断水螅毒素诱导的电导的反应。降低跨管状上皮的电位。在较高浓度下，会阻断Na+/H+交换途径。
血管生成抑制剂。在约130 µM时完全可逆地抑制毛细血管形态发生。在低浓度下，可作为跨膜Na+进入和Na+，K+-ATPase的有效和特异性抑制剂。也可作为尿激酶型纤溶酶原激活物（uPA）的抑制剂。阻断平滑肌对骨骼肌中收缩刺激和水螅毒素诱导的电导的反应。降低跨管状上皮的电位。在较高浓度下，会阻断Na+/H+交换途径。
生化／生理作用
主要靶标
毛细血管形态发生
毛细血管形态发生
产物不与ATP竞争。
可逆性：是
细胞渗透性：否
靶标IC50：130 µM 完全可逆地抑制毛细血管形态发生
警告
毒性：有毒（F）
重構
复溶后，等分并冷冻保存（-20°C）。储备水溶液在-20°C可稳定保存长达6个月。
其他說明
Knoll, A., et al. 1999.Microvasc.Res.58, 1.
Swiercz, R., et al. 1999.Oncol.Rep.6, 523.
Moran, A., et al. 1995.Am. J. Physiol.268, C350.
Alliegro, M.C., et al. 1993.J. Exp.Zool.267, 245.
Sugiyama, S., et al. 1988.J. Biol. Chem.263, 8215.
Yoshida, K., et al. 1988.Biochem.Biophys.Res. Commun.154, 101.
Sariban-Sotorabay, S., and Benos, D.J. 1986.Am. J. Physiol.250, C175.
Swiercz, R., et al. 1999.Oncol.Rep.6, 523.
Moran, A., et al. 1995.Am. J. Physiol.268, C350.
Alliegro, M.C., et al. 1993.J. Exp.Zool.267, 245.
Sugiyama, S., et al. 1988.J. Biol. Chem.263, 8215.
Yoshida, K., et al. 1988.Biochem.Biophys.Res. Commun.154, 101.
Sariban-Sotorabay, S., and Benos, D.J. 1986.Am. J. Physiol.250, C175.
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法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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