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Merck
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主要文件

07-817

Sigma-Aldrich

Anti-phospho-Glycogen Synthase(Ser641/Ser645) Antibody

Upstate®, from rabbit

别名:

Glycogen synthase 1, GYS1, GS

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About This Item

UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物来源

rabbit

质量水平

100

抗体形式

affinity purified immunoglobulin

抗体产品类型

primary antibodies

克隆

polyclonal

纯化方式

affinity chromatography

种属反应性

human, mouse

制造商/商品名称

Upstate®

技术

western blot: suitable

同位素/亚型

IgG

NCBI登记号

NM_002103.3

UniProt登记号

P13807

运输

dry ice

靶向翻译后修饰

phosphorylation (pSer641/pSer645)

基因信息

human ... GYS1(2997)

特异性

Glycogen Synthase phosphorylated on serine residues 641 and 645
Predicted to cross-react with rat based on sequence homology (100%), but have not been tested.

免疫原

Peptide corresponding to amino acid region encompassing the human, mouse, and rat phospho-Glycogen Synthase (Ser641/Ser645).

应用

Anti-phospho-Glycogen Synthase(Ser641/Ser645) Antibody is an antibody against phospho-Glycogen Synthase(Ser641/Ser645) for use in WB.
Research Sub Category
Insulin/Energy Signaling

PI3K, Akt, & mTOR Signaling

质量

Routinely evaluated by immunoblot.

目标描述

85 kDa

外形

Affinity purified rabbit polyclonal IgG in Dulbecco’s PBS, pH 7.3 with 1.0 mg/mL BSA, 0.05% sodium azide, and 50% glycerol.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Laura Marr et al.
Nature communications, 13(1), 3372-3372 (2022-06-12)
Glycogen is the major glucose reserve in eukaryotes, and defects in glycogen metabolism and structure lead to disease. Glycogenesis involves interaction of glycogenin (GN) with glycogen synthase (GS), where GS is activated by glucose-6-phosphate (G6P) and inactivated by phosphorylation. We
C T Shearn et al.
Biochemistry, 50(19), 3984-3996 (2011-03-29)
The production of reactive aldehydes such as 4-hydroxy-2-nonenal (4-HNE) is a key component of the pathogenesis in a spectrum of hepatic diseases involving oxidative stress such as alcoholic liver disease (ALD). One consequence of ALD is increased insulin resistance in
Tom A Gardiner et al.
Investigative ophthalmology & visual science, 56(13), 8008-8018 (2016-01-01)
It is widely held that neurons of the central nervous system do not store glycogen and that accumulation of the polysaccharide may cause neurodegeneration. Since primary neural injury occurs in diabetic retinopathy, we examined neuronal glycogen status in the retina
Sophia Maschalidi et al.
Nature, 606(7915), 776-784 (2022-05-26)
Chronic non-healing wounds are a major complication of diabetes, which affects 1 in 10 people worldwide. Dying cells in the wound perpetuate the inflammation and contribute to dysregulated tissue repair1-3. Here we reveal that the membrane transporter SLC7A11 acts as
Cole D Davidson et al.
Journal of the Endocrine Society, 5(8), bvab102-bvab102 (2021-07-15)
Thyroid cancer is the most common endocrine malignancy, and the global incidence has increased rapidly over the past few decades. Anaplastic thyroid cancer (ATC) is highly aggressive, dedifferentiated, and patients have a median survival of fewer than 6 months. Oncogenic
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