07-1341
抗PHLPP1抗体
from rabbit, purified by affinity chromatography
别名:
PH domain and leucine rich repeat protein phosphatase, PH domain leucine-rich repeat protein phosphatase, Pleckstrin homology domain-containing family E protein 1, SCN circadian oscillatory protein, Suprachiasmatic nucleus circadian oscillatory protein
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所有图片(3)
About This Item
UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41
推荐产品
生物来源
rabbit
质量水平
偶联物
conjugate
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
liquid
纯化方式
affinity chromatography
种属反应性
rat, mouse, human
技术
immunocytochemistry: suitable
western blot: suitable
免疫原序列
KLH-conjugated linear peptide corresponding to the C-terminus of PHLPP1.
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
2-8°C
基因信息
human ... PHLPP1(23239)
一般描述
PHLPP1是负责Akt (Ser473)位点去磷酸化的蛋白磷酸酶。Akt (Ser473)是TORC2 (mTOR)磷酸化激活位点。
特异性
该抗体可识别PHLPP1的C端。
免疫原
KLH偶联的线性肽，对应于PHLPP1的C端。
表位：C端
应用
抗PHLPP1抗体检测PHLPP1的水平 & 已发布 & 经验证可用于WB & IC。
研究子类别
PI3K、Akt & mTOR 信号传导
PI3K、Akt & mTOR 信号传导
研究类别
信号传导
信号传导
质量
通过蛋白质印迹在人脑组织裂解物中进行了评估。
蛋白质印迹分析：该抗体的1：1,000稀释液可在人脑组织裂解液中检测到PHLPP1。
蛋白质印迹分析：该抗体的1：1,000稀释液可在人脑组织裂解液中检测到PHLPP1。
目标描述
134 kDa 在110 kDa下观察
外形
亲和纯化
纯化的兔血清，溶于含有0.1 M Tris-甘氨酸（pH 7.4）、150 mM NaCl和0.05％叠氮化钠的缓冲液中。
储存及稳定性
自接收之日起，在2-8°C下冷藏保存1年。
分析说明
对照
人脑组织裂解液
人脑组织裂解液
其他说明
浓度：请参考批次特异性浓缩物的检验报告。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Saida Abdelli et al.
PloS one, 7(5), e35997-e35997 (2012-05-09)
We have recently shown that silencing of the brain/islet specific c-Jun N-terminal Kinase3 (JNK3) isoform enhances both basal and cytokine-induced beta-cell apoptosis, whereas silencing of JNK1 or JNK2 has opposite effects. While it is known that JNK1 or JNK2 may
Changli Zhang et al.
JOR spine, 7(1), e1306-e1306 (2024-01-15)
Intervertebral disc (IVD) degeneration is associated with chronic back pain. We previously demonstrated that the phosphatase pleckstrin homology domain and leucine-rich repeat protein phosphatase (PHLPP) 1 was positively correlated with IVD degeneration and its deficiency decelerated IVD degeneration in both
Ismael Y Karkache et al.
JBMR plus, 7(12), e10806-e10806 (2023-12-22)
Prior work demonstrated that Phlpp1 deficiency alters limb length and bone mass, but the cell types involved and requirement of Phlpp1 for this effect were unclear. To understand the function of Phlpp1 within bone-forming osteoblasts, we crossed Phlpp1 floxed mice
Medha Sharma et al.
Cell communication and signaling : CCS, 20(1), 179-179 (2022-11-16)
The aim of the present study was to determine the role of individual PHLPP isoforms in insulin signaling and insulin resistance in neuronal cells. PHLPP isoforms were either silenced or overexpressed individually, and the effects were observed on individual Akt
Travis C Jackson et al.
Scientific reports, 5, 9377-9377 (2015-04-02)
Pleckstrin homology domain and leucine rich repeat protein phosphatase 1 (PHLPP1) is a member of the serine/threonine family of phosphatases. It has been studied in organs including brain, heart, pancreas, adipose, breast, and prostate. Human PHLPP1 encodes two splice variants
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