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Merck
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Key Documents

05-730

Sigma-Aldrich

Anti-STEP Antibody, clone 23E5

clone 23E5, Upstate®, from mouse

别名:

Neural-specific protein-tyrosine phosphatase, PTPN5

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

mouse

品質等級

抗體表格

purified antibody

抗體產品種類

primary antibodies

無性繁殖

23E5, monoclonal

物種活性

mouse, rat, human

製造商/商標名

Upstate®

技術

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

同型

IgG

NCBI登錄號

UniProt登錄號

運輸包裝

dry ice

目標翻譯後修改

unmodified

基因資訊

human ... PTPN5(84867)

特異性

STEP61, STEP46, STEP38 and STEP20

免疫原

Peptide corresponding to amino acids 57-74 of rat STEP46

應用

Anti-STEP Antibody, clone 23E5 is an antibody against STEP for use in IP, WB, IH.
Research Category
Neuroscience
Research Sub Category
Ion Channels & Transporters

Neurodegenerative Diseases

品質

routinely evaluated by immunoblot on in RIPA lysates from whole rat brain preparations

標靶描述

~64-66 (doublet) & 46

外觀

Protein G Purified
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified

儲存和穩定性

2 years at -20°C

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1


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A protein tyrosine phosphatase expressed within dopaminoceptive neurons of the basal ganglia and related structures.
Lombroso, P J, et al.
The Journal of Neuroscience, 13, 3064-3074 (1993)
Jun Chen et al.
The European journal of neuroscience, 29(2), 287-306 (2009-02-10)
Although the mechanisms underlying striatal neurodegeneration are poorly understood, we have shown that striatal pathogenesis may be initiated by high synaptic levels of extracellular dopamine (DA). Here we investigated in rat striatal primary neurons the mobilization of the mitogen-activated protein
Daniel Radzicki et al.
Hippocampus, 33(3), 133-149 (2023-02-11)
Hippocampal area CA2 is a molecularly and functionally distinct region of the hippocampus that has classically been defined as the area with large pyramidal neurons lacking input from the dentate gyrus and the thorny excrescences (TEs) characteristic of CA3 neurons.
Serena M Dudek et al.
Hippocampus, 33(6), 700-711 (2023-05-09)
Since 1959, the Russian Farm-Fox study has bred foxes to be either tame or, more recently, aggressive, and scientists have used them to gain insight into the brain structures associated with these behavioral features. In mice, hippocampal area CA2 has
Sofía Espinoza et al.
BMC biology, 18(1), 164-164 (2020-11-08)
Cognitive dysfunction (CD) is common among patients with the autoimmune disease systemic lupus erythematosus (SLE). Anti-ribosomal P autoantibodies associate with this dysfunction and have neuropathogenic effects that are mediated by cross-reacting with neuronal surface P antigen (NSPA) protein. Elucidating the

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