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Merck

860658P

Avanti

sphinganine-d7

Avanti Research - A Croda Brand 860658P, powder

别名:

D-erythro-sphinganine-d7

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About This Item

经验公式(希尔记法):
C18H32D7NO2
分子量:
308.55
分類程式碼代碼:
12352211
NACRES:
NA.25

形狀

powder

包裝

pkg of 1 × 1 mg (860658P-1mg)

製造商/商標名

Avanti Research - A Croda Brand 860658P

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

OC[C@@](N)([H])[C@@](O)([H])CCCCCCCCCCCCC(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H]

一般說明

Sphinganine-d7 is a deuterated derivative of sphinganine. Sphinganine, also called as dihydrosphingosine is a derivative of sphingosine. Sphinganines are produced in endoplasmic reticulum, by decarboxylating condensation of palmitoyl-CoA and serine.

應用

Sphinganine-d7 has been used as an internal standard for quantification of sphingolipid concentrations in plasma and tissue samples by high-performance liquid chromatography tandem mass spectrometry.

生化/生理作用

Sphinganine (SPA) acts as a selective inhibitor of protein kinase C in intact human neutrophils. It may function a potential biomarker for the diagnosis of sphingolipidoses. SPA accumulation enables fumonisin B1 to stimulate apoptosis. It also has an ability to block cholesterol transport in Niemann-Pick Type C (NPC) disease.

包裝

5 mL Amber Glass Screw Cap Vial (860658P-1mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids


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Gennaro Bruno et al.
Cellular signalling, 45, 110-121 (2018-02-07)
Skeletal muscle tissue retains a remarkable regenerative capacity due to the activation of resident stem cells that in pathological conditions or after tissue damage proliferate and commit themselves into myoblasts. These immature myogenic cells undergo differentiation to generate new myofibers
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Basic neurochemistry: principles of molecular, cellular, and medical neurobiology (2011)
Federica Storti et al.
eLife, 8 (2019-03-14)
Age-related macular degeneration (AMD) is a progressive disease of the retinal pigment epithelium (RPE) and the retina leading to loss of central vision. Polymorphisms in genes involved in lipid metabolism, including the ATP-binding cassette transporter A1 (ABCA1), have been associated
Graham Brogden et al.
Biomolecules, 9(9) (2019-09-11)
Sphingolipids are an important group of lipids that play crucial roles in living cells, facilitating cell recognition, signal transduction and endocytosis. The concentration of sphingosine and some of its derivatives like sphinganine may serve as a biomarker for the diagnosis
Irina Alecu et al.
Journal of lipid research, 58(1), 60-71 (2016-11-23)
The 1-deoxysphingolipids (1-deoxySLs) are atypical sphingolipids (SLs) that are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during SL synthesis. The 1-deoxySLs are toxic to neurons and pancreatic β-cells. Pathologically elevated 1-deoxySLs cause the inherited neuropathy, hereditary

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