推荐产品
品質等級
化驗
≥90%
形狀
solid
顏色
orange to dark red
儲存溫度
−20°C
SMILES 字串
[O-]P(OCC[N+](C)(C)C)(OC[C@H](OC(CCCC1=CC(Cl)=C(C(Cl)=C1)/N=N/C2=C(C=C(C=C2Cl)CCCC)Cl)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O
InChI
1S/C46H72Cl4N3O8P/c1-6-8-10-11-12-13-14-15-16-17-18-19-20-21-22-26-43(54)58-34-38(35-60-62(56,57)59-29-28-53(3,4)5)61-44(55)27-23-25-37-32-41(49)46(42(50)33-37)52-51-45-39(47)30-36(24-9-7-2)31-40(45)48/h30-33,38H,6-29,34-35H2,1-5H3/b52-51+/t38-/m1/s1
一般說明
The NanoFabTx Photoactivatable Lipid, redAzoPC is a red-light photoswitchable lipid for controlled and targeted drug delivery. The tetra-ortho-chloro-azobenzene of redAzoPC can be isomerized from the cis to the trans conformation at 660 nm light. LNPs prepared using the NanoFabTx™ Photoactivatable Lipid, redAzoPC result in controlled drug release following deep red light irradiation.
應用
Lipid nanoparticle and liposome drug delivery systems
特點和優勢
- Similar drug loading, encapsulation efficiency, size, and polydispersity to non-photoswitchable lipids
- Light-induced drug delivery
- Targeted and controlled release
- Overcomes limitations associated to UV-switchable lipids
法律資訊
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
历史批次信息供参考:
Nisha Chander et al.
Small (Weinheim an der Bergstrasse, Germany), 17(21), e2008198-e2008198 (2021-04-22)
Encapsulation of small molecule drugs in long-circulating lipid nanoparticles (LNPs) can reduce toxic side effects and enhance accumulation at tumor sites. A fundamental problem, however, is the slow release of encapsulated drugs from these liposomal systems at the disease site
Tufan K Mukhopadhyay et al.
Current opinion in pharmacology, 63, 102202-102202 (2022-03-13)
Many aspects of cell signaling are controlled by lipids. Several signaling lipids have been functionalized with an azobenzene photoswitch to control underlying signaling dynamics with light. Herein, we provide an overview of signaling photolipids developed to date focusing on their
Johannes Morstein et al.
Chembiochem : a European journal of chemical biology, 22(1), 73-83 (2020-08-14)
Photoswitchable lipids are emerging tools for the precise manipulation and study of lipid function. They can modulate many aspects of membrane biophysics, including permeability, fluidity, lipid mobility and domain formation. They are also very useful in lipid physiology and enable
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