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Merck

914487

Sigma-Aldrich

2-(Diphenylphosphanyl)benzamide

≥95%

别名:

2-(Diphenylphosphino)-benzamide, DPBM, Phosphine for Staundinger reduction

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About This Item

经验公式(希尔记法):
C19H16NOP
分子量:
305.31
分類程式碼代碼:
12352200
NACRES:
NA.22

品質等級

化驗

≥95%

形狀

powder

儲存溫度

−20°C

一般說明

It is recommended to make fresh stock stolutions prior to each use.

應用

2-(Diphenylphosphanyl)benzamide (DPBM) is a phosphine useful in the Staudinger reduction in chemical biology and medicinal chemistry. Recently, DPBM was demonstrated to faciliate the reactivation of CRISPR/Cas9 functions by removing azidomethylnicotinyl (AMN) groups used to masked gRNA and inhibit CRISPR systems. AMN groups were originally added with the use of RNA probe NAI-N3 (cat# 913812).

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3


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Shao-Ru Wang et al.
Nature communications, 11(1), 91-91 (2020-01-05)
Prokaryotes use repetitive genomic elements termed CRISPR (clustered regularly interspaced short palindromic repeats) to destroy invading genetic molecules. Although CRISPR systems have been widely used in DNA and RNA technology, certain adverse effects do occur. For example, constitutively active CRISPR

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