914223

Biotin-SLF

• 别名: (R)-3-(3,4-Dimethoxyphenyl)-1-(3-(4,18-dioxo-22-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-8,11,14-trioxa-5,17-diazadocosanamido)phenyl)propyl (S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate, Bio-SLF, Biotin-conjugated FKBP12WT-directed ligand, Biotin-conjugated SLF ligand, FKBP12WT affinity probe for PROTAC^® and targeted protein degradation research
• 经验公式（希尔记法）: C₅₂H₇₆N₆O₁₃S
• CAS号: 2230857-85-7
• 分子量: 1025.26
• MDL编号: MFCD33021721
• UNSPSC代码: 12352200
• NACRES: NA.22

属性

• ligand: biotin
• 质量水平: 100
• 表单: powder
• 储存温度: −20°C
• SMILES字符串: O=C(CCC(NCCOCCOCCOCCNC(CCCC[C@@H]1SC[C@@](N2)([H])[C@]1([H])NC2=O)=O)=O)NC3=CC([C@H](OC([C@@H]4CCCCN4C(C(C(C)(C)CC)=O)=O)=O)CCC5=CC=C(OC)C(OC)=C5)=CC=C3
• InChI key: QFIMAWUXIBINCP-SLBVAARVSA-N

说明

应用

Biotin-SLF (bio-SLF) is an FKBP12^WT affinity probe useful in chemical biology or targeted protein degradation where FKBP12 is used as a tool protein and its enrichment is required in discovery experiments or assay validation.


Related tools:
Additional bifunctional tools for FKPB12 variants:

• dTAG-13 (SML2601) for FKBP12^F36V; and KB02-SLF (914738), KB03-SLF (914975), and KB04-SLF (913715) for FKBP12WT
• Cereblon (CRBN) affinity probe: Biotin-Thalidomide (913979)

Automate your Biotin tagging with Synple Automated Synthesis Platform (SYNPLE-SC002)

其他说明

The dTAG system for immediate and target-specific protein degradation

Technology Spotlight: Building PROTAC^® Degraders for Targeted Protein Degradation

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全信息

• 储存分类代码: 10 - Combustible liquids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable