911690

C5 Lenalidomide

≥95%

• 别名: 3-(5-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione, E3 ligase ligand, Ligand for PROTAC^® research
• 经验公式（希尔记法）: C₁₃H₁₃N₃O₃
• CAS号: 191732-70-4
• 分子量: 259.26
• MDL编号: MFCD31692701
• UNSPSC代码: 12352101
• NACRES: NA.22

属性

• ligand: C5 Lenalidomide
• 质量水平: 100
• 方案: ≥95%
• 表单: powder
• 反应适用性: reagent type: ligand
• 储存温度: 2-8°C
• SMILES字符串: NC1=CC=C2C(CN(C3CCC(NC3=O)=O)C2=O)=C1
• InChI: 1S/C13H13N3O3/c14-8-1-2-9-7(5-8)6-16(13(9)19)10-3-4-11(17)15-12(10)18/h1-2,5,10H,3-4,6,14H2,(H,15,17,18)
• InChI key: WLUIQUZGNPAKRL-UHFFFAOYSA-N

说明

应用

C5 Lenalidomide is a derivative of the Cereblon (CRBN)-binding ligand lenalidomide, which possesses an amine at the C4 position. C5 Lenalidomide can be used to bind the CRBN E3 ubiquitin ligase in targeted protein degradation research or in the synthesis of protein degraders with a C5 exit vector. Learn more about proteolysis-targeting chimeras (PROTACs) and the building blocks to design them in our Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

其他说明

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Amino-substituted thalidomide analogs: potent inhibitors of TNF-alpha production

Targeted Protein Degradation by Small Molecules

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全信息

• 象形图: GHS08
• 警示用语：: Warning
• 危险声明: H361d,H373
• 预防措施声明: P202 - P260 - P280 - P308 + P313 - P405 - P501
• 危险分类: Repr. 2 - STOT RE 2
• 靶器官: Blood
• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable