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Merck

900914

Sigma-Aldrich

Methyltetrazine-NHS ester

≥95%

别名:

2,5-Dioxo-1-pyrrolidinyl 4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzeneacetate

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About This Item

经验公式(希尔记法):
C15H13N5O4
分子量:
327.29
MDL號碼:
分類程式碼代碼:
12352108
NACRES:
NA.22

品質等級

化驗

≥95%

形狀

powder or crystals

反應適用性

reaction type: click chemistry
reagent type: cross-linking reagent

官能基

NHS ester

儲存溫度

−20°C

SMILES 字串

O=C(ON1C(CCC1=O)=O)CC(C=C2)=CC=C2C3=NN=C(C)N=N3

應用

Methyltetrazine-NHS ester has an N-hydroxysuccinimide (NHS) ester that can be reacted with primary amines and a methyltetrazine, which is reactive to trans-cyclooctenes. The NHS ester reacts with primary amines (e.g. side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic pH to form covalent bonds. The short spacer arm adds minimal mass to modified molecules (230.2 daltons). It is generally used in click chemistry applications in bioconjugate chemistry.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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High-Throughput Chemical Probing of Full-Length Protein?Protein Interactions.
Song J M, et al.
ACS Combinatorial Science, 19(12), 763-769 (2017)
A click chemistry-based microRNA maturation assay optimized for high-throughput screening.
Lorenz D A and Garner A L
Chemical Communications (Cambridge, England), 52(53), 8267-8270 (2016)
An anti-B cell maturation antigen bispecific antibody for multiple myeloma.
Ramadoss N S, et al.
Journal of the American Chemical Society, 137(16), 5288-5291 (2015)
Biodegradable tetra-PEG hydrogels as carriers for a releasable drug delivery system.
Henise J, et al.
Bioconjugate Chemistry, 26(2), 270-278 (2015)

商品

Choosing the right crosslinker for your biochemical or bioconjugation research can be challenging. Our selection guide can help you find the perfect match for your applications.

在生化或生物偶联研究中,如何选择适合的交联剂令人苦恼。我们的选择指南可以帮助您找到与应用最匹配的产品。

Choosing the right crosslinker for your biochemical or bioconjugation research can be challenging. Our selection guide can help you find the perfect match for your applications.

Choosing the right crosslinker for your biochemical or bioconjugation research can be challenging. Our selection guide can help you find the perfect match for your applications.

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