719641

(4S)-2-[2-(二苯基膦)苯基]-4,5-二氢-5,5-二甲基-4-(1-甲基乙基)-噁唑

97%

• 别名: (S)-2-(2-(二苯基膦)苯基)-4-异丙基-5,5-二甲基-4,5-二氢噁唑, (S)-5,5-(二甲基)-i-Pr-PHOX
• 经验公式（希尔记法）: C₂₆H₂₈NOP
• CAS号: 1152313-76-2
• 分子量: 401.48
• MDL编号: MFCD16621462
• UNSPSC代码: 12352005
• PubChem化学物质编号: 329763666
• NACRES: NA.22

属性

• 质量水平: 100
• 方案: 97%
• 表单: solid
• mp: 124-128 °C
• 官能团: ether; phosphine
• SMILES字符串: CC(C)[C@@H]1N=C(OC1(C)C)c2ccccc2P(c3ccccc3)c4ccccc4
• InChI: 1S/C26H28NOP/c1-19(2)24-26(3,4)28-25(27-24)22-17-11-12-18-23(22)29(20-13-7-5-8-14-20)21-15-9-6-10-16-21/h5-19,24H,1-4H3/t24-/m0/s1
• InChI key: JGUZEKBWCGNHHN-DEOSSOPVSA-N

说明

应用

Use of 5,5-(Dimethyl)-i-Pr-PHOX as a Practical Equivalent to t-Bu-PHOX in Asymmetric Catalysis

Design, Synthesis, and Applications of Potential Substitutes of t-Bu-Phosphinooxazoline in Pd-Catalyzed Asymmetric Transformations and Their Use for the Improvement of the Enantioselectivity in the Pd-Catalyzed Allylation Reaction of Fluorinated Allyl Enol Carbonates

(S)-5,5-(Dimethyl)-i-Pr-PHOX is a phosphinooxazoline ligand (PHOX), belongs to the class of non-C₂ symmetric chiral ligand.
It can be used in:

• The enantioselective Pd-catalyzed allylation reactions.
• The synthesis of (R)-2-phenyl-2,5-dihydrofuran by the enantioselective Heck reaction between 2,3-dihydrofuran and phenyl triflate.
• The allylation reaction of fluorinated allyl enol carbonates and fluorinated silyl enol ethers to prepare allylated tert α-fluoroketones.

安全信息

• 象形图: GHS06
• 警示用语：: Danger
• 危险声明: H301,H315,H319,H335,H413
• 预防措施声明: P261 - P264 - P273 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• 危险分类: Acute Tox. 3 Oral - Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 靶器官: Respiratory system
• 储存分类代码: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable