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质量水平
方案
95%
表单
liquid
折射率
n20/D 1.373 (lit.)
沸点
66-67 °C (lit.)
密度
0.87 g/mL at 25 °C (lit.)
官能团
O-nitroso
nitroso
储存温度
2-8°C
SMILES字符串
CC(C)CON=O
InChI
1S/C4H9NO2/c1-4(2)3-7-5-6/h4H,3H2,1-2H3
InChI key
APNSGVMLAYLYCT-UHFFFAOYSA-N
一般描述
亚硝酸异丁酯广泛用作室内除臭剂。这是一种流行的娱乐药物。
应用
亚硝酸异丁酯用于研究吸入剂诱导的免疫毒性。
警示用语：
Danger
危险分类
Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Flam. Liq. 2 - Muta. 2
储存分类代码
3 - Flammable liquids
WGK
WGK 3
闪点(°F)
-5.8 °F - closed cup
闪点(°C)
-21 °C - closed cup
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Inhaled isobutyl nitrite produced lung inflammation with increased macrophage TNF-alpha and nitric oxide production.
L S Soderberg et al.
Advances in experimental medicine and biology, 402, 187-189 (1996-01-01)
Review of the physiological effects of amyl, butyl, and isobutyl nitrites.
T J Haley
Clinical toxicology, 16(3), 317-329 (1980-05-01)
W Kielbasa et al.
AAPS pharmSci, 2(2), E11-E11 (2001-12-14)
Our objective was to examine the pharmacokinetic/hemodynamic properties of inhaled isobutyl nitrite (ISBN) in rats. ISBN is one of the volatile organic nitrites that has been used primarily as a drug of abuse. Recent studies indicate, however, that these compounds
L S F Soderberg et al.
Toxicology letters, 152(1), 47-56 (2004-08-06)
Epidemiological studies have identified abuse of nitrite inhalants as an independent co-factor in HIV infection and in Kaposi's sarcoma (KS) in AIDS patients. In the present study we investigated the ability of macrophages from mice exposed to isobutyl nitrite to
L S Soderberg et al.
Experimental hematology, 24(7), 848-853 (1996-06-01)
Isobutyl nitrite is representative of a group of inhalants abused primarily by male homosexuals; abuse of this drug may be a risk factor for AIDS or Kaposi's sarcoma. Using a 14-day exposure regimen, we previously reported that inhaled isobutyl nitrite
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