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Merck
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文件

224189

Sigma-Aldrich

4-(氟磺酰)苯甲酸

95%

别名:

4-羧基苯磺酰氟, 对-（氟磺酰基）苯甲酸

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About This Item

线性分子式:
FSO2C6H4CO2H
CAS号:
455-26-5
分子量:
204.18
EC號碼:
207-243-3
MDL號碼:
MFCD00007420
分類程式碼代碼:
12352100
PubChem物質ID:
24853421
NACRES:
NA.22

化驗

95%

形狀

solid

反應適用性

reaction type: click chemistry

mp

272-273 °C (lit.)

SMILES 字串

OC(=O)c1ccc(cc1)S(F)(=O)=O

InChI

1S/C7H5FO4S/c8-13(11,12)6-3-1-5(2-4-6)7(9)10/h1-4H,(H,9,10)

InChI 密鑰

DJUJJHDCOUPERR-UHFFFAOYSA-N

相关类别

一般說明

4-（氟磺酰基）苯甲酸是一种异源生物底物类似物，与大鼠肝谷胱甘肽S-转移酶的4-4同工酶孵育后会导致该酶的时间依赖性失活。

應用

4-（氟磺酰基）苯甲酸用作二聚体猪肺pi类谷胱甘肽S-转移酶的亲和标记。

象形圖

Corrosion
GHS05

訊號詞

Danger

危險聲明

H314

危險分類

Skin Corr. 1B

儲存類別代碼

8A - Combustible corrosive hazardous materials

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Lisa L Moore et al.
Journal of proteome research, 3(6), 1184-1190 (2004-12-15)
Proteins that bind ATP and GTP are important cellular components. We developed an immunological approach to selectively tag nucleotide-binding proteins based on the use of 5'-[4-(fluorosulfonyl)benzoyl]adenosine and 5'-[4-(fluorosulfonyl)benzoyl]guanosine affinity tags and an antibody against 4-(sulfonyl)benzoate. Detection follows affinity labeling, gel
J J Barycki et al.
Biochemistry, 32(48), 13002-13011 (1993-12-07)
Incubation of 4-(fluorosulfonyl)benzoic acid (4-FSB), a xenobiotic substrate analogue, with the 4-4 isozyme of rat liver glutathione S-transferase at pH 7.5 and 25 degrees C results in a time-dependent inactivation of the enzyme. The rate of inactivation exhibits a nonlinear
J Wang et al.
Protein science : a publication of the Protein Society, 5(6), 1032-1042 (1996-06-01)
Reaction of rat liver glutathione S-transferase, isozyme 1-1, with 4-(fluorosulfonyl)benzoic acid (4-FSB), a xenobiotic substrate analogue, results in a time-dependent inactivation of the enzyme to a final value of 35% of its original activity when assayed at pH 6.5 with
N E Pettigrew et al.
Archives of biochemistry and biophysics, 364(1), 107-114 (1999-03-24)
The compound 4-(fluorosulfonyl)benzoic acid (4-FSB) functions as an affinity label of the dimeric pig lung pi class glutathione S-transferase yielding a completely inactive enzyme. Protection against inactivation is provided by glutathione-based ligands, suggesting that the reaction target is near or

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