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Merck

155268

Sigma-Aldrich

(R)-(+)-α-甲氧基-α-三氟甲基苯乙酸

99%

别名:

(+)-MTPA, Mosher 酸

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About This Item

线性分子式:
C6H5C(OCH3)(CF3)CO2H
CAS号:
分子量:
234.17
Beilstein:
3591560
EC號碼:
MDL號碼:
分類程式碼代碼:
12352112
PubChem物質ID:
NACRES:
NA.22

化驗

99%

形狀

solid

光學活性

[α]20/D +72°, c = 1.6 in methanol

光學純度

ee: 99% (GLC)

折射率

n20/D 1.473 (lit.)

bp

105-107 °C/1 mmHg (lit.)

mp

46-49 °C (lit.)

密度

1.344 g/mL at 25 °C (lit.)

儲存溫度

2-8°C

SMILES 字串

CO[C@@](C(O)=O)(c1ccccc1)C(F)(F)F

InChI

1S/C10H9F3O3/c1-16-9(8(14)15,10(11,12)13)7-5-3-2-4-6-7/h2-6H,1H3,(H,14,15)/t9-/m1/s1

InChI 密鑰

JJYKJUXBWFATTE-SECBINFHSA-N

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應用

(R)-(+)-α-Methoxy-α-trifluoromethylphenylacetic acid is commonly used as a derivatizing agent in Mosher ester analysis, an NMR-based method for determining the absolute configuration of the chiral carbon center in a secondary alcohol.

包裝

Bottomless glass bottle. Contents are inside inserted fused cone.

其他說明

doi:10.1038/nprot.2007.354

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

235.4 °F - closed cup

閃點(°C)

113 °C - closed cup

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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其他客户在看

Slide 1 of 1

1 of 1

Tetrahedron Asymmetry, 18, 975-975 (2007)
Lidia De Luca et al.
The Journal of organic chemistry, 72(10), 3955-3957 (2007-04-11)
An effective route to chiral optically active 2-substituted benzofurans directly from carboxylic acids is reported. This procedure, which allows the preparation of alpha-alkyl-2-benzofuranmethanamines from N-protected alpha-amino acids without sensible racemization phenomena, proceeds in good yields under mild conditions with the
Mosher ester analysis for the determination of absolute configuration of stereogenic (chiral) carbinol carbons.
Hoye TR, et al.
Nature Protocols, 2(10), 2451-2458 (2007)
Giancarlo Cravotto et al.
Chirality, 16(8), 526-533 (2004-08-04)
Cyclodextrin (CD) derivatives are important selectors for analytical chiral recognition. Their enantioselectivities and chemical properties depend on ring size and on nature, number and location of substituents. This paper describes the synthesis of 6-O-TBDMS-2,3-O-methyl beta-cyclodextrins bearing in position 2 either
J Martín Torres-Valencia et al.
Phytochemical analysis : PCA, 13(6), 329-332 (2002-12-24)
A method to determine the absolute configuration of 2,3-epoxy-2-methylbutanoate ester residues in natural products is presented, based on (i) the reduction of the ester function to yield a 2-methyl-1,2-butanediol, (ii) esterification of the obtained primary alcohol with either (R)-(+)- or

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