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一般描述
二氟乙酸是一种单羧酸，也是一种有机氟化合物。二氟乙酸是一种易于操作的试剂，用于制备二氟甲基取代基。二氟乙酸可用作直接对杂环化合物进行C−H二氟甲基化的二氟甲基化试剂。
应用
用于在三苯基膦的介导下，由邻位取代苯胺制备 2-二氟化甲基苯并咪唑、-噁唑和-噻唑。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A
储存分类代码
8A - Combustible corrosive hazardous materials
WGK
WGK 3
闪点(°F)
172.4 °F - closed cup
闪点(°C)
78 °C - closed cup
个人防护装备
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
其他客户在看
Hoffman B M Lantum et al.
Toxicological sciences : an official journal of the Society of Toxicology, 70(2), 261-268 (2002-11-21)
Dichloroacetic acid (DCA), chlorofluoroacetic acid (CFA), and difluoroacetic acid (DFA) are inhibitors of pyruvate dehydrogenase kinase. DCA is used for the clinical management of congenital lactic acidosis. Glutathione transferase zeta (GSTZ1-1) catalyzes the biotransformation of DCA and CFA, and DCA
J M Dalstein et al.
Comptes rendus des seances de la Societe de biologie et de ses filiales, 174(5), 821-825 (1980-01-01)
In the anesthetized rat, the intraperitoneal injection of 40 mg/kg sodium difluoroacetate (DFA), an activator of the pyruvate dehydrogenase, counteracted the hyperlactatemia induced by a high dose of phenformin (40 mg/kg) injected concomitantly. In the normal conscious dog, the administration
Gaëlle Blond et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 8(13), 2917-2922 (2002-12-20)
Ethers of trifluoroacetaldehyde hemiaminals can undergo dehydrofluorination under basic conditions to provide ethers of difluoroketene hemiaminals. The latter behave as equivalents of difluoroacetamide or difluoroacetate anions towards various electrophiles, yielding a range of difluoromethylcarbonyl products.
J N Commandeur et al.
Biochemical pharmacology, 37(23), 4495-4504 (1988-12-01)
The biotransformation and the hepato- and nephrotoxicity of the mercapturic acids (N-acetyl-1-cysteine S-conjugates) of three structurally related 2,2-difluoroethylenes were investigated in vivo in the rat. All mercapturic acids appeared to cause nephrotoxicity, without any measureable effect on the liver. The
Tetrahedron Letters, 48, 3251-3251 (2007)
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