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应用
苯磺酰胺被用于开发同时测定环境水中苯并三唑、苯并噻唑和苯磺酰胺污染物的分析方法 。
生化/生理作用
苯磺酰胺是人碳酸酐酶 B 的抑制剂 。苯磺酰胺衍生物对治疗癌症等增殖性疾病有效 。用于合成染料、光化学物和消毒剂 。
制备说明
苯磺酰胺溶于甲醇,浓度为 25 mg/mL,形成澄清、无色溶液。
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Asha Chandran et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 92, 84-90 (2012-03-27)
The FT-IR and FT-Raman spectra of (E)-N-carbamimidoyl-4-((4-methoxybenzylidene)amino)benzenesulfonamide were recorded and analyzed. Geometry and harmonic vibrational wavenumbers were calculated theoretically using Gaussian 03 set of quantum chemistry codes. Calculations were performed at the Hartree-Fock (HF) and density functional theory (DFT) levels
Nitrogen-15 nuclear magnetic resonance study of benzenesulfonamide and cyanate binding to carbonic anhydrase.
K Kanamori et al.
Biochemistry, 22(11), 2658-2664 (1983-05-24)
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Here we describe how a (19)F-probe incorporated into an endogenous protein by a chemical biology method revealed protein dynamics. By explicit determination of ligand-bound and unbound structures with X-ray crystallography, the quantitative comparison of the protein's dynamics in live cells
Genliang Lu et al.
Journal of medicinal chemistry, 56(2), 510-520 (2012-12-14)
Carbonic anhydrase IX (CA-IX) is upregulated in cancer in response to the hypoxic tumor microenvironment, making it an attractive molecular target for the detection of hypoxic solid tumors. A series of small molecule benzenesulfonamide based CA-IX inhibitors containing novel tridentate
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Bioorganic & medicinal chemistry, 20(17), 5254-5261 (2012-07-27)
The P2Y(1) receptor (P2Y(1)R) is a G protein-coupled receptor naturally activated by extracellular ADP. Its stimulation is an essential requirement of ADP-induced platelet aggregation, thus making antagonists highly sought compounds for the development of antithrombotic agents. Here, through a virtual
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