SAB4502010
Anti-NNOS antibody produced in rabbit
affinity isolated antibody
Synonym(s):
BNOS, Constitutive NOS, N-NOS, NC-NOS, bNOS
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About This Item
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biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 160 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... NOS1(4842)
General description
Anti-NNOS antibody detects endogenous levels of total NNOS protein.
The NNOS (nitric oxide synthase 1) gene is mapped to human chromosome 12q24.22. Neuronal nitric oxide synthase is known to be expressed in skeletal muscles, the heart and the brain.
Immunogen
The antiserum was produced against synthesized peptide derived from human nNOS.
Immunogen Range: 818-867
Immunogen Range: 818-867
Application
Anti-NNOS antibody produced in rabbit has been used in immunohistochemistry.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Immunohistochemistry (1 paper)
Biochem/physiol Actions
NNOS (nitric oxide synthase 1) is responsible for the synthesis of NO (nitric oxide) as well as superoxide. Stress induces the activity of NNOS and generation of NO and results in the formation of nitrogen radicals. Elevation of nitrogen radical leads to intracellular protein damage and also induces impairment to mitochondrial transport chain components. This generally results in cellular energy deficiency. NNOS is known to regulate vasodilation in the forearm, in response to stress. Neuronal nitric oxide synthase normally functions to control the basal coronary blood flow.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Hideshi Ihara et al.
The Biochemical journal, 474(7), 1149-1162 (2017-01-28)
We previously demonstrated different spacial expression profiles of the neuronal nitric oxide (NO) synthase (nNOS) splice variants nNOS-µ and nNOS-α in the brain; however, their exact functions are not fully understood. Here, we used electron paramagnetic resonance to compare the
A Kumar et al.
Vitamins and hormones, 103, 147-167 (2017-01-08)
Stress is often marked by a state of hyperarousal to aid the initiation of necessary stress response for the successful management of stressful stimuli. It can be manifested as a challenge (stimulus) that requires behavioral, psychological, and physiological adaptations for
Anna Svenningsson et al.
Journal of human genetics, 57(2), 115-121 (2011-12-14)
Infantile hypertrophic pyloric stenosis (IHPS) is a common cause of upper gastrointestinal obstruction during infancy. A multifactorial background of the disease is well established. Multiple susceptibility loci including the neuronal nitric oxide synthase (NOS1) gene have previously been linked to
G Catanzaro et al.
Journal of neuroimmunology, 294, 32-40 (2016-05-04)
The development of multiple sclerosis, a major neurodegenerative disease, is due to both genetic and environmental factors that might trigger aberrant epigenetic changes of the genome. In this study, we analysed global DNA methylation in the brain of mice upon
Katherine J Robinson et al.
Psychopharmacology, 239(9), 2903-2919 (2022-08-04)
Methamphetamine (METH, "ice") is a potent and addictive psychostimulant. Abuse of METH perturbs neurotransmitter systems and induces neurotoxicity; however, the neurobiological mechanisms which underlie addiction to METH are not fully understood, limiting the efficacy of available treatments. Here we investigate
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