D5794

Diacylglycerol Kinase Inhibitor II

solid

• Synonym(s): 3-[2-[4-(bis(4-Fluorophenyl)methylene)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone, R59949
• Empirical Formula (Hill Notation): C₂₈H₂₅F₂N₃OS
• CAS Number: 120166-69-0
• Molecular Weight: 489.58
• MDL number: MFCD00069258
• UNSPSC Code: 41106300
• PubChem Substance ID: 24278378
• NACRES: NA.77

Properties

• biological source: synthetic (organic)
• Assay: ≥97% (HPLC)
• form: solid
• color: pale yellow
• mp: 228-230 °C
• solubility: 0.1 M HCl: slightly soluble; 0.1 M NaOH: slightly soluble; DMSO: soluble; H₂O: insoluble; ethanol: soluble; ethyl acetate: soluble
• storage temp.: −20°C
• SMILES string: Fc1ccc(cc1)\C(=C2\CCN(CCN3C(=S)Nc4ccccc4C3=O)CC2)c5ccc(F)cc5
• InChI: 1S/C28H25F2N3OS/c29-22-9-5-19(6-10-22)26(20-7-11-23(30)12-8-20)21-13-15-32(16-14-21)17-18-33-27(34)24-3-1-2-4-25(24)31-28(33)35/h1-12H,13-18H2,(H,31,35)
• InChI key: ZCNBZFRECRPCKU-UHFFFAOYSA-N

Description

Application

Diacylglycerol Kinase Inhibitor II has been used to determine tumor-induced inhibition with genetically modified cytotoxic T cells expressing chimeric antigen receptors (CAR). It has also been used to induce pAkt and PKR-like extracellular signal-regulated kinase (pErk) signals in T-cell acute lymphoblastic leukemia (T-ALL) cells.

Biochem/physiol Actions

Diacylglycerol kinase inhibitor. Inhibits formation of [³⁸P]1-Oleoyl-2-acetylglyceryl-3-phosphoric acid (OAPA) in red blood cell membranes: IC₅₀ = 3.3 μM.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves