B1636

Pentagastrin

≥95% (HPLC), powder, CCK2 receptor agonist

• Synonym(s): Peptavlon, Petogasrin, N-t-Boc-β-Ala-Trp-Met-Asp-Phe amide
• Empirical Formula (Hill Notation): C₃₇H₄₉N₇O₉S
• CAS Number: 5534-95-2
• Molecular Weight: 767.89
• EC Number: 226-889-7
• MDL number: MFCD00076515
• UNSPSC Code: 12352200
• PubChem Substance ID: 24891602
• NACRES: NA.77

Properties

• product name: Pentagastrin, ≥95% (HPLC), powder
• Assay: ≥95% (HPLC)
• form: powder
• storage condition: (Keep container tightly closed in a dry and well-ventilated place.)
• color: white to off-white
• solubility: DMF: 20 mg/mL, clear, colorless to faint yellow or tan
• storage temp.: −20°C
• SMILES string: CSCCC(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)NC(CC(O)=O)C(=O)NC(Cc3ccccc3)C(N)=O
• InChI: 1S/C37H49N7O9S/c1-37(2,3)53-36(52)39-16-14-30(45)41-28(19-23-21-40-25-13-9-8-12-24(23)25)34(50)42-26(15-17-54-4)33(49)44-29(20-31(46)47)35(51)43-27(32(38)48)18-22-10-6-5-7-11-22/h5-13,21,26-29,40H,14-20H2,1-4H3,(H2,38,48)(H,39,52)(H,41,45)(H,42,50)(H,43,51)(H,44,49)(H,46,47)
• InChI key: NEYNJQRKHLUJRU-UHFFFAOYSA-N
• Gene Information: mouse ... Cckbr(12426) ; rat ... Cckar(24889) , Cckbr(25706)

Description

Amino Acid Sequence

Boc-Bal-Trp-Met-Asp-Phe-NH2

General description

Research area: Immunology & cytokines

Application

Pentagastrin has been used to bidirectionally modulate lateral nucleus of the amygdala (LA) activity. It has also been used as a cholecystokinin-2 receptor (CCK2R) agonist to block the receptor binding for Ga-DOTA-MGS5 in AR42J rat pancreatic cell lines during cell uptake and receptor binding studies.

Biochem/physiol Actions

Pentagastrin, a synthetic polypeptide is a gastrin analog. It contains the five C-terminal amino acids of gastrin. It acts as a cholecystokinin-2 (CCK2) receptor/ cholecystokinin-B (CCKB) receptor agonist. Pentagastrin stimulates the secretion of pepsin and gastric acid. It also aids in the evaluation of gastric acid secretory function. Pentagastrin exhibits panicogenic/ anxiogenic effects and thereby induces panic attacks in panic disorder (PD) patients.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable