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A6757

Sigma-Aldrich

D-Arginine monohydrochloride

≥98% (TLC)

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About This Item

Empirical Formula (Hill Notation):
C6H14N4O2 · HCl
CAS Number:
627-75-8
Molecular Weight:
210.66
Beilstein:
5773432
EC Number:
211-010-1
MDL number:
MFCD00012620
UNSPSC Code:
12352209
PubChem Substance ID:
24891136
NACRES:
NA.77

product name

D-Arginine monohydrochloride, ≥98% (TLC)

Assay

≥98% (TLC)

form

powder

color

white

mp

216-218 °C

application(s)

cell analysis
peptide synthesis

SMILES string

Cl.N[C@H](CCCNC(N)=N)C(O)=O

InChI

1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m1./s1

InChI key

KWTQSFXGGICVPE-PGMHMLKASA-N

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Application

D-arginine attenuates increased arginase expression, oxidative stress, endothelial dysfunction, and advanced glycation endproducts formation induced by methylgloxyl and high glucose. This attenuation by D-arginine is thought to occur through an endothelial NOS independent mechanism.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A simple method of preparing D-(minus)-arginine monohydrochloride from DL-arginine.
C P Berg et al.
Analytical biochemistry, 63(1), 68-72 (1975-01-01)
Phuong V Tran et al.
Biochemical and biophysical research communications, 533(4), 965-970 (2020-10-04)
Central administration of L-arginine was reported to attenuate stress responses in neonatal chicks. The present study aimed to elucidate the differential effects of centrally administered L-arginine and its enantiomer, D-arginine, on the stress response in chicks and the associated mechanisms.
D-arginine attenuates methylglyoxal- and high glucose-induced endothelial dysfunction and oxidative stress by an eNOS-independent mechanism
Dahr, I., et al.
Journal of Pharmacology and Experimental Therapeutics, 63, 196-204 (2012)
Ruo-Xiao Cheng et al.
Theranostics, 9(15), 4287-4307 (2019-07-10)
Methylglyoxal (MGO), an endogenous reactive carbonyl compound, plays a key role in the pathogenesis of diabetic neuropathy. The aim of this study is to investigate the role of MGO in diabetic itch and hypoalgesia, two common symptoms associated with diabetic

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