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306M-2

Sigma-Aldrich

NSE (MRQ-55) Mouse Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

MRQ-55, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (306M-24)
vial of 0.5 mL concentrate (306M-25)
bottle of 1.0 mL predilute (306M-27)
vial of 1.0 mL concentrate (306M-26)
bottle of 7.0 mL predilute (306M-28)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200

isotype

IgG2b

control

appendix/colon, schwannoma

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... ENO2(2026)

General description

Neuron-specific enolase (NSE) is a glycolytic isoenzyme of the enolase gamma-gamma dimerselectively detected in neurons, peripheral nerves, some neuroendocrine cells, and tumors.NSE immunoreactivity is also observed, to a lesser extent, in smooth muscle tissue. Anti-NSEis often used to visualize peripheral nerves and for the identification of neuroendocrinedifferentiation.

Quality


IVD
IVD
IVD
RUO

Linkage

NSE Positive Control Slides, Product No. 306S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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N Leonard et al.
Gut, 37(6), 763-765 (1995-12-01)
The pathogenesis of villous damage in coeliac disease is unknown. Change to the delicate neuromuscular core may be significant and this study stained various categories of coeliac disease and controls with neuron-specific enolase (NSE) to examine neurofilaments in the mucosa.
E H Cooper
The International journal of biological markers, 9(4), 205-210 (1994-10-01)
The clinical value of neuron-specific enolase as a marker is small cell lung cancer, neuroblastoma, melanoma and seminoma has been reviewed. The role of serum and cerebrospinal NSE in benign and malignant disease of the central nervous system is discussed.
A S Leong et al.
Pathology, 18(4), 393-399 (1986-10-01)
Thirteen cases of primary endocrine carcinoma of the skin (Merkel cell carcinoma) were reviewed with the aim of defining the morphological, immunohistochemical and ultrastructural criteria for diagnosis. The tumour cells were characterized by their scanty cytoplasm, generally small uniform nuclei
M R Wick et al.
American journal of clinical pathology, 79(6), 703-707 (1983-06-01)
In order to better define the use of neuron-specific enolase (NSE) as a marker for neuroendocrine neoplasms, we studied 11 thymic carcinoid tumors, three bronchial small-cell carcinomas (all with cutaneous metastases), and 10 trabecular carcinomas of the skin for its
S A Vinores et al.
Archives of pathology & laboratory medicine, 108(7), 536-540 (1984-07-01)
In normal conditions, neuron-specific enolase (NSE) is histochemically demonstrable only in neurons and cells of the amine precursor uptake and decarboxylation (APUD) system. This has been found not to be true for neoplastic cells. Several types of CNS tumors, including

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