Skip to Content
Merck
All Photos(5)

Documents

311448

Sigma-Aldrich

Sodium periodate

ACS reagent, ≥99.8%

Synonym(s):

Sodium (meta)periodate

Sign Into View Organizational & Contract Pricing
All Photos(5)

About This Item

Linear Formula:
NaIO4
CAS Number:
7790-28-5
Molecular Weight:
213.89
EC Number:
232-197-6
MDL number:
MFCD00003534
UNSPSC Code:
12352302
PubChem Substance ID:
329753668
NACRES:
NA.21

grade

ACS reagent

Quality Level

200

Assay

≥99.8%
99.8-100.3% dry basis (ACS specification)

form

crystalline powder

reaction suitability

reagent type: oxidant

impurities

≤0.02% other halogens (as Cl)

pH

3.5-5.5 (25 °C, 107 g/L)

mp

300 °C (dec.) (lit.)

cation traces

Mn: ≤3 ppm

storage temp.

room temp

SMILES string

[Na+].[O-]I(=O)(=O)=O

InChI

1S/HIO4.Na/c2-1(3,4)5;/h(H,2,3,4,5);/q;+1/p-1

InChI key

JQWHASGSAFIOCM-UHFFFAOYSA-M

Looking for similar products? Visit Product Comparison Guide

General description

Sodium periodate is an inorganic salt commonly used as an oxidizing agent for various organic substrates and a co-oxidant in a few other oxidation reactions. The oxidation of sodium periodate takes place in a water medium, but an organic co-solvent is used for organic substrates that are insoluble in water.

Application

Sodium periodate can be used as an oxidizing agent:
  • In the selective oxidation of sulfides to sulfoxides.
  • For the oxidative cleavage of a variety of 1,2-diols to generate aldehydes or ketones.
  • In the oxidation of diaryl, dialkyl, and aryl alkyl selenides to the respective selenoxides.
  • In the selective alkene epoxidation and alkane hydroxylation reactions.
  • In the selective oxidation of activated cellulose to obtain dialdehyde cellulose (DAC) by cleavage of the bond between C2 – C3 in the glucose unit.
  • It can also be used as an iodinating agent for the iodination of arenes and halo compounds.

Signal Word

Danger

Hazard Statements

H271,H314,H372,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Ox. Sol. 1 - Skin Corr. 1C - STOT RE 1

Target Organs

Thyroid

Storage Class Code

5.1A - Strongly oxidizing hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 1

1 of 1

2-Keto-3-deoxyoctonate ammonium salt ≥97%

Sigma-Aldrich

K2755

2-Keto-3-deoxyoctonate ammonium salt

Synthesis, 64-64 (1989)
Millicent Winner et al.
Cancer research, 68(18), 7253-7257 (2008-09-17)
Although chemokine and growth factor receptors are attractive and popular targets for cancer therapeutic intervention, structure-based targeting of the ligands themselves is generally not considered practical. New evidence indicates that a notable exception to this is macrophage migration inhibitory factor
Carrie E Brubaker et al.
Biomaterials, 31(3), 420-427 (2009-10-09)
There is significant need for effective medical adhesives that function reliably on wet tissue surfaces with minimal inflammatory insult. To address these performance characteristics, we have generated a synthetic adhesive biomaterial inspired by the protein glues of marine mussels. In-vivo
Leonhard Möckl et al.
Developmental cell, 50(1), 57-72 (2019-05-21)
The mammalian glycocalyx is a heavily glycosylated extramembrane compartment found on nearly every cell. Despite its relevance in both health and disease, studies of the glycocalyx remain hampered by a paucity of methods to spatially classify its components. We combine
Maria Molinos et al.
Biomacromolecules, 13(2), 517-527 (2012-02-01)
Dextrin, a glucose polymer with low molecular weight, was used to develop a fully resorbable hydrogel, without using chemical initiators. Dextrin was first oxidized (oDex) with sodium periodate and then cross-linked with adipic acid dihidrazide, a nontoxic cross-linking molecule. Furthermore
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service