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Key Documents

MAB5204

Sigma-Aldrich

Anti-Agrin Antibody

Chemicon®, from mouse

Synonym(s):

Anti-AGRIN, Anti-CMSPPD

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

monoclonal

species reactivity

mouse, rat

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... AGRN(375790)

Specificity

MAB5204 recognizes rat and mouse agrin. The epitope has been mapped near the splicing site Z. Binding of this antibody to agrin causes marked reduction in nAChR clusters.

Immunogen

Recombinant rat agrin (C-terminal construct)

Application

Anti-Agrin Antibody is an antibody against Agrin for use in WB & IC.
Immunocytochemistry: 10 μg/mL

Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Research Sub Category
Growth Cones & Axon Guidance

Synapse & Synaptic Biology

Physical form

Format: Purified
Purified immunoglobulin. Liquid in PBS containing 50% glycerol and 0.09% sodium azide.

Storage and Stability

Maintain lyophilized at material -20°C or below for up to 12 months. After reconstitution maintain at -20°C to -70°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Nandor Nagy et al.
Development (Cambridge, England), 145(9) (2018-04-22)
The enteric nervous system (ENS) arises from neural crest cells that migrate, proliferate, and differentiate into enteric neurons and glia within the intestinal wall. Many extracellular matrix (ECM) components are present in the embryonic gut, but their role in regulating
The COOH-terminal domain of agrin signals via a synaptic receptor in central nervous system neurons.
Hoover, CL; Hilgenberg, LG; Smith, MA
The Journal of cell biology null
Paul J Thomas et al.
The American journal of pathology, 186(9), 2429-2448 (2016-08-27)
Overexpression of B4GALNT2 (previously GALGT2) inhibits the development of muscle pathology in mouse models of Duchenne muscular dystrophy, congenital muscular dystrophy 1A, and limb girdle muscular dystrophy 2D. In these models, muscle GALGT2 overexpression induces the glycosylation of α dystroglycan
Silvia Scaricamazza et al.
British journal of pharmacology, 179(8), 1732-1752 (2021-11-17)
Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the degeneration of upper and lower motor neurons, progressive wasting and paralysis of voluntary muscles and is currently incurable. Although considered to be a pure motor neuron disease, increasing evidence indicates
Zhenxi Zhang et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(48), 19348-19353 (2013-11-06)
The motor neuron (MN) degenerative disease, spinal muscular atrophy (SMA) is caused by deficiency of SMN (survival motor neuron), a ubiquitous and indispensable protein essential for biogenesis of snRNPs, key components of pre-mRNA processing. However, SMA's hallmark MN pathology, including

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