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Sigma-Aldrich

JMV 2959

≥97% (HPLC), powder, Ghrelin receptor antagonist, Calbiochem®

Synonym(s):

Ghrelin Receptor Antagonist, JMV 2959, Growth hormone secretagogue receptor antagonist, (R)-N-(2-(1H-indol-3-yl)-1-(4-(4-methoxybenzyl)-5-phenethyl-4H-1,2,4-triazol-3-yl)ethyl)-2-aminoacetamide hydrochloride, GHSR1a Antagonist, GH secretagogue receptor antagonist, JMV2959

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About This Item

Empirical Formula (Hill Notation):
C30H32N6O2 · xHCl
Molecular Weight:
508.61 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77

product name

Ghrelin Receptor Antagonist, JMV 2959,

Assay

≥97% (HPLC)

Quality Level

100

form

powder

potency

32 nM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

beige

solubility

DMSO: 100 mg/mL
water: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

JMV 2959, which blocks the signaling of the growth hormone secretagogue receptor 1A, reduces the deficits in prepulse inhibition induced by the NMDAR antagonist, phencyclidine.

Application

Ghrelin Receptor Antagonist, JMV 2959 has been used to examine oxytocin receptor (OTR) and ghrelin receptor (GHSR) signaling. It has also been used as a GHS-R1a receptor antagonist to pretreat Hek cells followed by pyridone 8 exposure to study its effect on GHS-R1a receptor-mediated calcium influx.

Biochem/physiol Actions

Primary Target
Ghrelin receptor

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Physical form

Supplied as a hydrochloride salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Moulin, A., et al. 2013. Amino Acids44, 301.
Mary, S., et al. 2012. Proc Natl Acad Sci USA109, 8304.
Salome, N., et al. 2009. Eur J Pharmacol.612, 167,.
Moulin, A., et al. 2007. J Med Chem50, 579.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A ghrelin receptor and oxytocin receptor heterocomplex impairs oxytocin mediated signalling
Fitzsimons SEW, et al.
Neuropharmacology, 152, 90-101 (2019)
Blockade of growth hormone secretagogue receptor 1A signaling by JMV 2959 attenuates the NMDAR antagonist, phencyclidine-induced impairments in prepulse inhibition
Engel JA, et al.
Psychopharmacology, 232, 4285-4292 (2015)
A novel non-peptidic agonist of the ghrelin receptor with orexigenic activity in vivo
Pastor-Cavada E, et al.
Scientific Reports, 6(1), 36456-36456 (2016)
A novel non-peptidic agonist of the ghrelin receptor with orexigenic activity in vivo
Pastor-Cavada E, et al.
Scientific reports, 6(1), 36456-36456 (2016)

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