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Key Documents

199311

Sigma-Aldrich

Tetrabromophenol Blue

Dye content 75 %

Synonym(s):

3,3′,3″,4,5,5′,5″,6-Octabromophenolsulfonphthalein

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About This Item

Empirical Formula (Hill Notation):
C19H6Br8O5S
CAS Number:
Molecular Weight:
985.54
Beilstein:
378438
EC Number:
MDL number:
UNSPSC Code:
12171500
PubChem Substance ID:
NACRES:
NA.47

Assay

≥75.0% (HPLC)

form

powder

composition

Dye content, 75%

mp

204 °C (dec.) (lit.)

λmax

388 nm (2nd)
605 nm

ε (extinction coefficient)

≥55000 at 606-616 nm in ethanol and water

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

Oc1c(Br)cc(cc1Br)C2(OS(=O)(=O)c3c(Br)c(Br)c(Br)c(Br)c23)c4cc(Br)c(O)c(Br)c4

InChI

1S/C19H6Br8O5S/c20-7-1-5(2-8(21)16(7)28)19(6-3-9(22)17(29)10(23)4-6)11-12(24)13(25)14(26)15(27)18(11)33(30,31)32-19/h1-4,28-29H

InChI key

QPMIVFWZGPTDPN-UHFFFAOYSA-N

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Biochem/physiol Actions

Tetrabromophenol Blue (TBPB) belongs to the group of sulfonephthalein acid-base indicators. It is employed in the potentiometric titration of the halogens with Hg2(NO3)2. In addition, it has been used as a dye indicator in urine dipstick test to detect proteinuria. In this assay, with increasing concentration of urinary protein, TBPB sequentially changes color from pale green to blue. Binding of TBPB to proteins is dependent on pH.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Urine proteomics: the present and future of measuring urinary protein components in disease.
Barratt J and Topham P
CMAJ : Canadian Medical Association Journal = Journal de l'Association Medicale Canadienne, 177, 361-368 (2007)
David S. Breslow, Herman Skolnik
Multi-Sulfur and Sulfur and Oxygen Five- and Six-Membered Heterocycles, Part 1 (2009)
Liping Li et al.
Analytica chimica acta, 1062, 102-109 (2019-04-06)
The facile detection of phosphopeptides is important for clinical screening and phosphoproteomic research. This work develops an instrument-free, cost-effective, convenient paper-based method for quantitative analysis of phosphorylated peptides. With a novel portable device, Phos-PAD, this method can achieve selective enrichment
Andrea Pastore et al.
Sensors (Basel, Switzerland), 20(21) (2020-10-30)
A pH colorimetric sensor array was prepared and characterized by combining tetrabromophenol blue (TBB) and bromothymol blue (BB) embedded in organically modified silicate (OrMoSil) spots polyvinylidene fluoride (PVDF)-supported. The signal was based on the Hue profile (H). The individual calibrations
Xiaolu Xiong et al.
Biochip journal, 1-9 (2020-11-05)
In order to improve the efficiency of disease diagnosis and environmental monitoring, it is desirable to detect the concentration of proteins and metal ions simultaneously, since the current popular diagnostic platform can only detect proteins or metal ions independently. In

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