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Key Documents

WH0050674M1

Sigma-Aldrich

Monoclonal Anti-NEUROG3 antibody produced in mouse

clone 4B7, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-Atoh5, Anti-Math4B, Anti-neurogenin 3, Anti-ngn3

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About This Item

MDL number:
MFCD01633905
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

4B7, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunofluorescence: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL

isotype

IgG2bκ

GenBank accession no.

NM_020999

UniProt accession no.

Q9Y4Z2

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... NEUROG3(50674)

General description

Neurogenin 3 (NEUROG3) is also termed as Ngn3. This protein belongs to the subfamily of basic-helix-loop-helix (bHLH) transcription factors. It is located on human chromosome 10q.
Neurogenin-3 (NEUROG3) is expressed in endocrine progenitor cells and is required for endocrine cell development in the pancreas and intestine (Wang et al., 2006 [PubMed 16855267]). It belongs to a family of basic helix-loop-helix transcription factors involved in the determination of neural precursor cells in the neuroectoderm (Gradwohl et al., 2000 [PubMed 10677506]).[supplied by OMIM]

Immunogen

NEUROG3 (NP_066279, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MTPQPSGAPTVQVTRETERSFPRASEDEVTCPTSAPPSPTRTRGNCAEAEEGGCRGAPRKLRARRGGRSRPKSELALSKQRRSRRKKANDRERNRMHNLN*

Biochem/physiol Actions

Neurogenin 3 (NEUROG3) is required for all intestinal enteroendocrine cells. It participates in the differentiation of endocrine pancreas. This protein is also essential to induce islet cell maturation and to maintain islet function.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function
Wang S, et al.
Proceedings of the National Academy of Sciences of the USA, 106(24), 9715-9720 (2009)
Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium
Gerbe F, et al.
The Journal of Cell Biology, 192(5), 767-780 (2011)
Polymorphisms in the neurogenin 3 gene (NEUROG) and their relation to altered insulin secretion and diabetes in the Danish Caucasian population
Jensen JN, et al.
Diabetologia, 44(1), 123-126 (2001)
Abel L Carcagno et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(46), 15223-15233 (2014-11-14)
The development of the nervous system is critically dependent on the production of functionally diverse neuronal cell types at their correct locations. In the embryonic neural tube, dorsoventral signaling has emerged as a fundamental mechanism for generating neuronal diversity. In

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