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S9317

Sigma-Aldrich

PAR-2 (1-6) amide (mouse, rat) trifluoroacetate salt

≥97% (HPLC)

Synonym(s):

PAR2-AP, SLIGRL−NH2, Ser-Leu-Ile-Gly-Arg-Leu-amide trifluoroacetate salt

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About This Item

Empirical Formula (Hill Notation):
C29H56O7N10 · C2HF3O2
Molecular Weight:
770.84
MDL number:
MFCD03093421
UNSPSC Code:
51111800
PubChem Substance ID:
329824620
NACRES:
NA.32

Quality Level

200

Assay

≥97% (HPLC)

form

solid

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(N)=O

InChI

1S/C29H56N10O7/c1-7-17(6)23(39-27(45)21(12-16(4)5)38-25(43)18(30)14-40)28(46)35-13-22(41)36-19(9-8-10-34-29(32)33)26(44)37-20(24(31)42)11-15(2)3/h15-21,23,40H,7-14,30H2,1-6H3,(H2,31,42)(H,35,46)(H,36,41)(H,37,44)(H,38,43)(H,39,45)(H4,32,33,34)/t17-,18-,19-,20-,21-,23-/m0/s1

InChI key

SGPMJRPYYIJZPC-JYAZKYGWSA-N

Amino Acid Sequence

Ser-Leu-Ile-Gly-Arg-Leu-NH2

Application

PAR-2 (1-6) amide (mouse, rat) trifluoroacetate salt has been used as a proteinase-activated receptor 2 (PAR-2) agonist to induce the expression of Hh and Hippo genes in Hek293A cells.

Biochem/physiol Actions

Selective proteinase-activated receptor 2 (PAR2) peptide agonist.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hyun Su Ha et al.
Archives of pharmacal research, 40(12), 1443-1454 (2017-11-04)
Protease-activated receptors (PARs) are a family of G protein-coupled receptors with a unique activation mechanism involving proteolytic cleavage of the extracellular N-terminal domain of the receptor. PAR2 has a contractile effect on esophageal smooth muscle. We investigate the signaling pathways
The Yes-associated protein controls the cell density regulation of Hedgehog signaling
M. Tariki
Oncogenesis (2014)
Chihiro Hirai et al.
Reproductive sciences (Thousand Oaks, Calif.), 23(11), 1542-1550 (2016-05-04)
The production of soluble fms-like tyrosine kinase 1 (sFLT1) by exogenous chymotrypsin in trophoblast cells through protease-activated receptor (PAR) 2 was investigated to identify the role of a chymotrypsin-like serine protease in preeclampsia (PE) pathogenesis. We evaluated the expression of
Tomoki Fukuyama et al.
BMC pharmacology & toxicology, 19(1), 37-37 (2018-07-05)
Topical administration of PR022, 0.05% hypochlorous acid (HOCl) in gel has been demonstrated to be beneficial in a chronic murine atopic dermatitis model. In a follow up study we tested a higher concentration (0.1%) of PR022 HOCl gel in comparison
Chengcheng Huang et al.
Frontiers in molecular neuroscience, 10, 205-205 (2017-07-14)
Itch, a sensation eliciting a desire to scratch, is distinct from but not completely independent of pain. Inspiring achievements have been made in the characterization of itch-related receptors and neurotransmitters, but the molecular mechanisms controlling the development of pruriceptors remain
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