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P0880

Sigma-Aldrich

Pro-Gly

≥98% (TLC), suitable for cell culture

Synonym(s):

L-prolyl-glycine

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About This Item

Empirical Formula (Hill Notation):
C7H12N2O3
CAS Number:
2578-57-6
Molecular Weight:
172.18
MDL number:
MFCD00022391
UNSPSC Code:
12352202
PubChem Substance ID:
24898135
NACRES:
NA.26

product name

Pro-Gly,

Assay

≥98% (TLC)

form

powder

technique(s)

cell culture | mammalian: suitable

color

white

application(s)

cell analysis

storage temp.

−20°C

SMILES string

OC(=O)CNC(=O)[C@@H]1CCCN1

InChI

1S/C7H12N2O3/c10-6(11)4-9-7(12)5-2-1-3-8-5/h5,8H,1-4H2,(H,9,12)(H,10,11)/t5-/m0/s1

InChI key

RNKSNIBMTUYWSH-YFKPBYRVSA-N

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Related Categories

Biochem/physiol Actions

PRO-GLY is a dipeptide that has previously been shown to prevent progression of diabetes.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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T A Gudasheva et al.
European journal of drug metabolism and pharmacokinetics, 22(3), 245-252 (1997-07-01)
The metabolism of a new piracetam analogue, the dipeptide cognitive enhancer N-phenylacetyl-L-prolylglycine ethyl ester (GVS-111) was studied in vivo. GVS-111 itself was not found in rat brain 1 h after 5 mg/kg i.p. administration up to limit of detection (LOD)
[Effects of dipeptides Gly-Pro, Pro-Gly, glycine, and proline on the cardiotropic effect of acetylcholine].
N E Babskaia et al.
Biulleten' eksperimental'noi biologii i meditsiny, 126(8), 139-141 (1998-10-20)
Daisuke Motooka et al.
Biopolymers, 98(2), 111-121 (2011-10-25)
Extensive studies on the structure of collagen have revealed that the hydroxylation of Pro residues in a variety of model peptides with the typical (X-Y-Gly)(n) repeats (X and Y: Pro and its analogues) represents one of the major factors influencing
Shigeo Hayakawa et al.
Journal of the American Chemical Society, 129(25), 7936-7949 (2007-06-07)
We report a combined experimental and computational study of the proline effect in model dipeptides Pro-Gly and Gly-Pro. Gas-phase protonated peptide ions were discharged by glancing collisions with potassium or cesium atoms at 3 keV collision energies, and the peptide
Feng-Chun Wu et al.
The Journal of organic chemistry, 74(13), 4812-4818 (2009-05-23)
Tetrapeptides, containing a terminated primary amine and conformationally restricted D-Pro-Gly or D-Pro-Aib (2-aminoisobutanoic acid) segment as a strongly beta-turn-nucleating element, were designed and synthesized with condensation of N-module dipeptides with C-module dipeptides in solution. They were first applied to catalyze
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