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Key Documents

F3272

Sigma-Aldrich

Inulin–FITC

from dahlia tuber

Synonym(s):

Fluorescein isothiocyanate–inulin

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About This Item

MDL number:
UNSPSC Code:
12352201
NACRES:
NA.25

biological source

dahlia tuber

Quality Level

form

powder

mol wt

2,000-5,000

color

light yellow to dark yellow, to dark orange

solubility

water: soluble, clear

storage temp.

2-8°C

Application


  • Development and validation of bioengineered intestinal tubules for translational research aimed at safety and efficacy testing of drugs and nutrients.: This study employs Inulin–FITC to investigate the absorption characteristics of bioengineered intestinal models, providing critical data on gut permeability and nutrient interaction, which is crucial for pharmaceutical and nutritional research (Jochems et al., 2019).

  • Role of Vitamin D in Maintaining Renal Epithelial Barrier Function in Uremic Conditions.: Utilizes Inulin–FITC to measure the efficacy of Vitamin D in preserving renal barrier function under stress conditions, which could lead to new treatments for chronic kidney disease (Mihajlovic et al., 2017).

  • Inhibition of p38 mitogen-activated protein kinase attenuates butyrate-induced intestinal barrier impairment in a Caco-2 cell monolayer model.: This investigation highlights the role of Inulin–FITC in studying the protective effects of kinase inhibition on intestinal barriers, relevant for gastrointestinal disorder treatments (Huang et al., 2014).

  • Measurement of glomerular filtration rate in conscious mice using FITC-inulin clearance.: Demonstrates the utility of Inulin–FITC in precise, non-invasive measurements of renal function, essential for nephrology research and therapy development (Qi and Breyer, 2009).

  • PPAR gamma agonist normalizes glomerular filtration rate, tissue levels of homocysteine, and attenuates endothelial-myocyte uncoupling in alloxan induced diabetic mice.: Incorporates Inulin–FITC to assess the efficacy of a PPAR gamma agonist in diabetic nephropathy, providing insights into metabolic disease management (Rodriguez et al., 2008).

Other Notes

To gain a comprehensive understanding of our extensive range of Oligosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Walter E Rodriguez et al.
International journal of biological sciences, 4(4), 236-244 (2008-08-12)
Homocysteine (Hcy) is an independent cardiovascular risk factor; however, in diabetes, the role of tissue Hcy leading to cardiac dysfunction is unclear. To determine whether tissue Hcy caused endothelial-myocyte uncoupling and ventricular dysfunction in diabetes. Diabetes was created in C57BL/6J
Richard B van Breemen et al.
Expert opinion on drug metabolism & toxicology, 1(2), 175-185 (2006-08-23)
Caco-2 cells are a human colon epithelial cancer cell line used as a model of human intestinal absorption of drugs and other compounds. When cultured as a monolayer, Caco-2 cells differentiate to form tight junctions between cells to serve as
Nicholas Ferrell et al.
Biotechnology and bioengineering, 107(4), 707-716 (2010-06-17)
We have developed a bilayer microfluidic system with integrated transepithelial electrical resistance (TEER) measurement electrodes to evaluate kidney epithelial cells under physiologically relevant fluid flow conditions. The bioreactor consists of apical and basolateral fluidic chambers connected via a transparent microporous
N T Baker et al.
Microbial pathogenesis, 49(5), 260-272 (2010-07-06)
Campylobacter fetus is a recognized pathogen of cattle and sheep, though human infection has also been reported. Ingestion of contaminated food or water is a proposed route of transmission for both humans and animals. The subsequent detection of the organism
Chunhua Jin et al.
Hypertension (Dallas, Tex. : 1979), 53(6), 1048-1053 (2009-05-13)
Studies were designed to determine the effects of increases of renal perfusion pressure on the production of hydrogen peroxide (H(2)O(2)) and NO(2)(-)+NO(3)(-) within the renal outer medulla. Sprague-Dawley rats were studied with either the renal capsule intact or removed to

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