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Supelco

Oxfendazole

VETRANAL®, analytical standard

Synonym(s):

Methyl 5-(phenylsulfinyl)-benzimidazol-2-carbamate

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About This Item

Empirical Formula (Hill Notation):
C15H13N3O3S
CAS Number:
53716-50-0
Molecular Weight:
315.35
EC Number:
258-714-5
MDL number:
MFCD00801063
UNSPSC Code:
41116107
PubChem Substance ID:
329754866
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

COC(=O)Nc1nc2cc(ccc2[nH]1)S(=O)c3ccccc3

InChI

1S/C15H13N3O3S/c1-21-15(19)18-14-16-12-8-7-11(9-13(12)17-14)22(20)10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19)

InChI key

BEZZFPOZAYTVHN-UHFFFAOYSA-N

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General description

Oxfendazole is a benzimidazole anthelmintic drug, effective against cysticercosis, echinococcosis and fasciolosis.
Oxfendazole is a member of benzimidazole group of anthelmintics.

Application

Oxfendazole may be used as a reference standard in the determination of oxfendazole in pharmaceutical preparations using reversed-phase high-performance liquid chromatography (RP-HPLC).
Oxfendazole may be used as an analytical reference standard for the determination of the analyte in bovine liver by liquid chromatography method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

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Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

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Product No.
Description
Pricing

Pictograms

Health hazardEnvironment
GHS08,GHS09

Signal Word

Danger

Hazard Statements

H360D,H373,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - STOT RE 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL3268
BCCG5828
BCCB2008
BCCB2006
BCBT4620

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C S Sikasunge et al.
Veterinary parasitology, 158(1-2), 57-66 (2008-10-07)
The aim of this study was to assess the effect of treating Taenia solium infected pigs with oxfendazole (OFZ) on viability and clearance of cysticerci and the corresponding persistence of specific antibody isotypes (IgG(total), IgG1, IgG2 and IgA) and circulating
L Moreno et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(10), 3819-3825 (2012-07-31)
Oxfendazole (OFZ) is efficacious for porcine cysticercosis at 30 mg/kg. OFZ is not registered to be used at this dose. The assessment of the OFZ and metabolites [(fenbendazole sulphone (FBZSO2), fenbendazole (FBZ)] plasma pharmacokinetic and tissue residue profiles after its
Yasuaki Dewa et al.
Archives of toxicology, 81(9), 647-654 (2007-03-07)
The effect of oxfendazole (OX), a benzimidazole anthelmintic, on hepatic gene expression was investigated in the liver of rats as a preliminary study to elucidate the possible mechanism of its non-genotoxic hepatocarcinogenesis. The liver from a male F344/N rat given
Chemotherapy of Gastrointestinal Helminths.
Handbook of Experimental Pharmacology, 77, 111-114 (2012)
Jihei Nishimura et al.
Archives of toxicology, 84(2), 143-153 (2009-12-25)
To clarify whether enzymatically modified isoquercitrin (EMIQ) or melatonin (MLT) supplementation reduces oxidative stress-mediated hepatocellular tumor-promoting effect of oxfendazole (OX), a benzimidazole anthelmintic, male rats were administered a single intraperitoneal injection of N-diethylnitrosamine (DEN) and were fed a diet containing
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