SML2196

Zotarolimus

≥95% (HPLC)

• Synonym(s): (42S)-42-Deoxy-42-(1H-tetrazol-1-yl)rapamycin, ABT-578
• Empirical Formula (Hill Notation): C₅₂H₇₉N₅O₁₂
• CAS Number: 221877-54-9
• Molecular Weight: 966.21
• UNSPSC Code: 51111800
• NACRES: NA.77
• MDL number: MFCD09752954
• Assay: ≥95% (HPLC)
• Form: powder

Properties

• assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: C[C@H](CC[C@@H](C[C@H](OC)/C(C)=C/C=C/C=C/[C@H](C[C@H](C([C@H](OC)[C@@H](/C(C)=C/[C@@H](C)C1=O)O)=O)C)C)O2)[C@]2(O)C(C(N3CCCC[C@H]3C(O[C@H]([C@H](C)C[C@@H]4CC[C@H](N5N=NN=C5)[C@H](OC)C4)C1)=O)=O)=O
• InChI: 1S/C52H79N5O12/c1-31-16-12-11-13-17-32(2)43(65-8)28-39-21-19-37(7)52(64,69-39)49(61)50(62)56-23-15-14-18-41(56)51(63)68-44(34(4)26-38-20-22-40(45(27-38)66-9)57-30-53-54-55-57)29-42(58)33(3)25-36(6)47(60)48(67-10)46(59)35(5)24-31/h11-13,16-17,25,30-31,33-35,37-41,43-45,47-48,60,64H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,32-17+,36-25+/t31-,33-,34-,35-,37-,38+,39+,40+,41+,43+,44+,45-,47-,48+,52-/m1/s1
• InChI key: CGTADGCBEXYWNE-JUKNQOCSSA-N

Description

Biochem/physiol Actions

Rapamycin analog with immunosuppressant and anti-proliferative activity used in coronary stents

Zotarolimus (ABT-578) is a semi-synthetic rapamycin analog with immunosuppressant and anti-proliferative activity. It binds to the FKBP12 binding protein, which subsequently binds to the mammalian target of rapamycin (mTOR) causing cell cycle arrest in the G1 phase. Zotarolimus was designed to be used for delivery from drug-eluting coronary stents to prevent restenosis.

Zotarolimus is a second generation Drug Eluting Stent (DES).

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3