SBR00015
AEBSF Ready Made Solution
Synonym(s):
4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C8H10FNO2S · HCl
CAS Number:
Molecular Weight:
239.69
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.85
Recommended Products
Assay
≥97%
Quality Level
form
liquid
storage condition
protect from light
shipped in
dry ice
storage temp.
−20°C
InChI
1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
InChI key
WRDABNWSWOHGMS-UHFFFAOYSA-N
Application
This solution is provided at 100 mM in water. The stock solution may be diluted 1:100 for a 1 mM working concentration. Recommended concentrations for use are 0.1-1.0 mM.
Biochem/physiol Actions
AEBSF is a specific irreversible serine protease inhibitor. It inhibits proteases like chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. AEBSF is an excellent alternative to available serine protease inhibitors as it offers superior inhibitory activity and much lower toxicological risk.
Other Notes
The stability of AEBSF decreases rapidly at higher temperatures and at a pH greater than 7.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Applied biochemistry and biotechnology, 48(2), 57-59 (1994-08-01)
Five enzyme inhibitors (phenylmethylsulfonyl fluoride, 4-amidinophenylmethanesulfonyl fluoride, 4-(2-aminoethyl)benzenesulfonyl fluoride, N alpha-p-tosyl-L-lysine chloromethyl ketone, and N-tosyl-L-phenylalanine chloromethyl ketone) in buffer, DMSO, or stock solutions were completely degraded by adding 1M NaOH and the final reaction mixtures were not mutagenic. The stability
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