Aquaporin 4 (AQP4) is expressed in the nervous system. The gene ID of the protein is 25293.
Specificity
Detects ~35 kDa. May detect larger glycosylated bands ~50 kDa.
Immunogen
C-terminal peptide
Biochem/physiol Actions
Aquaporin 4 (AQP4) functions as a water channel in the rat brain.
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Physical form
PBS, pH 7..4, 50% glycerol, and 0.09% sodium azide
Disclaimer
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Aquaporins (AQPs) are a family of transmembrane proteins involved in the maintenance of osmotic gradients. AQP4 is abundant in skeletal muscle, where it seems to be associated with glycolytic metabolism. We investigated the pattern of expression of AQP4 in normal
Trimethyltin chloride (TMT) is a neurotoxicant producing neuronal degeneration and reactive astrogliosis in the mammalian central nervous system, especially the hippocampus. A previous magnetic resonance imaging investigation in TMT-treated rats evidenced dilation of lateral ventricles, also suggesting alterations in blood-brain
Journal of neuroinflammation, 18(1), 181-181 (2021-08-23)
Intractable neuropathic pain is a common symptom of neuromyelitis optica spectrum disorder (NMOSD). However, the underlying mechanism of NMOSD pain remains to be elucidated. In this study, we focused on ATP, which is one of the damage-associated molecular patterns, and
Redistribution of the water channel aquaporin-4 (AQP4) away from astrocyte endfeet and into parenchymal processes is a striking histological feature in mouse models of Alzheimer's disease (AD) and other neurological conditions with prominent astrogliosis. AQP4 redistribution has been proposed to
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