SAB4300128
Anti-phospho-NOS3 (pSer1177) antibody produced in rabbit
affinity isolated antibody
Synonym(s):
ECNOS, NOS, NOSIII, eNOS
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About This Item
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 133 kDa
species reactivity
mouse, rat, human
concentration
1 mg/mL
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer1177)
Gene Information
human ... NOS3(4846)
Immunogen
Peptide sequence around phosphorylation site of serine 1177 (T-Q-S(p)-F-S), according to the protein NOS3.
Application
Recommended dilutions
Western Blot 1:500 - 1:1000
Optimal dilutions should be determined by the user.
Western Blot 1:500 - 1:1000
Optimal dilutions should be determined by the user.
Biochem/physiol Actions
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
Features and Benefits
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Physical form
Solution in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Naoyuki Otani et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 41(11), 923-931 (2018-09-07)
This study was designed to investigate the effects of uric acid on vascular endothelial function in measurements carried out either at the bedside or the laboratory bench. First, we performed reactive hyperemia peripheral arterial tonometry using an EndoPAT 2000 device
Yuki Hirano et al.
Cardiovascular research, 113(10), 1208-1218 (2017-05-05)
Although surfactant protein-D (SP-D) is a pneumoprotein that is predominantly synthesized by type II epithelial cells in the lung, individuals with increased circulating levels of SP-D are at an elevated risk of mortality from ischemic heart disease. Whether SP-D contributes
Deok Hwa Nam et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(1), 711-721 (2018-07-20)
Coordinated changes in signaling pathways and gene expression in hearts subjected to prolonged stress maintain cardiac function. Loss of steroid receptor coactivator-2 (SRC-2) results in a reversal to the fetal gene program and disrupts the response to pressure overload, accompanied
Szabolcs Zahorán et al.
Antioxidants (Basel, Switzerland), 10(4) (2021-05-01)
Nitric oxide (NO) bioavailability is fundamental in the regulation of redox balance and functionality of the endothelium, especially in the case of the umbilical cord (UC), which has no innervation. The analysis of UC vessel-related complications could serve as a
David C Reineke et al.
European journal of medical research, 20, 59-59 (2015-06-25)
Definitive fate of the coronary endothelium after implantation of a drug-eluting stent remains unclear, but evidence has accumulated that treatment with rapamycin-eluting stents impairs endothelial function in human coronary arteries. The aim of our study was to demonstrate this phenomenon
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