Skip to Content
Merck
All Photos(2)

Key Documents

P5084

Sigma-Aldrich

PTIO

Synonym(s):

2-Phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C13H17N2O2
CAS Number:
Molecular Weight:
233.29
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.32

form

powder

Quality Level

storage temp.

2-8°C

SMILES string

CC1(C)N([O])C(c2ccccc2)=[N+]([O-])C1(C)C

InChI

1S/C13H17N2O2/c1-12(2)13(3,4)15(17)11(14(12)16)10-8-6-5-7-9-10/h5-9H,1-4H3

InChI key

DYUUGILMVYJEHY-UHFFFAOYSA-N

Application

2-phenyl-4, 4, 5, 5,-tetramethylimidazoline-1-oxyl 3-oxide (PTIO) has been used as a nitric oxide (NO) scavenger.

Biochem/physiol Actions

2-phenyl-4, 4, 5, 5,-tetramethylimidazoline-1-oxyl 3-oxide (PTIOs) derivatives react with nitric oxide (NO) to yield the corresponding imino nitroxides (PTIs) and nitrogen dioxide (NO2).
A stable radical scavenger for nitric oxide; affects NO without affecting NO synthase; has significant inhibitory activity against NO biological actions.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Victoria P A Johnstone et al.
Learning & memory (Cold Spring Harbor, N.Y.), 18(10), 625-633 (2011-09-22)
Long-term potentiation (LTP) is an important process underlying learning and memory in the brain. At CA3-CA1 synapses in the hippocampus, three discrete forms of LTP (LTP1, 2, and 3) can be differentiated on the basis of maintenance and induction mechanisms.
Ekaterina Minaeva et al.
PloS one, 12(10), e0186851-e0186851 (2017-10-20)
Truncated hemoglobins constitute a large family, present in bacteria, in archaea and in eukaryotes. However, a majority of physiological functions of these proteins remains to be elucidated. Identification and characterization of a novel role of truncated hemoglobins in the model
Moonhee Lee et al.
Brain research, 1400, 99-111 (2011-06-07)
Activated monocytes/macrophages are known to release toxic materials. Identification of these materials is important for developing more effective treatments for inflammatory disorders where self attack occurs. We stimulated human monocytes and THP-1 cells with LPS/IFNγ and measured the toxic effects
Luca G Mariotti et al.
International journal of radiation biology, 88(10), 751-762 (2012-06-20)
To investigate the mechanisms regulating the pathways of the bystander transmission in vitro, focusing on the radiation-perturbed signalling (via Interleukine 6, IL-6) of the irradiated cells after exposure to low doses of different radiation types. An integrated 'systems radiation biology'
Involvement of nitric oxide in oxidative burst, phenylalanine ammonia-lyase activation and Taxol production induced by low-energy ultrasound in Taxus yunnanensis cell suspension cultures.
Wang JW
Nitric Oxide, 15(4), 351-358 (2006)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service