O4375

Oxytocin

lyophilized powder, ~15 IU/mg solid (Prepared from synthetic oxytocin)

• Synonym(s): α-Hypophamine, Oxytocic hormone
• Empirical Formula (Hill Notation): C₄₃H₆₆N₁₂O₁₂S₂
• CAS Number: 50-56-6
• Molecular Weight: 1007.19
• Beilstein: 3586108
• MDL number: MFCD00076731
• UNSPSC Code: 51111800
• PubChem Substance ID: 24897994
• NACRES: NA.32

Properties

• biological source: synthetic
• sterility: non-sterile
• form: lyophilized powder
• specific activity: ~15 IU/mg solid (Prepared from synthetic oxytocin)
• solubility: water: 10 mg/mL, clear, colorless
• UniProt accession no.: P01178; P30559; P70536
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)[C@@H](C)CC)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O
• InChI: 1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1
• InChI key: XNOPRXBHLZRZKH-DSZYJQQASA-N
• Gene Information: human ... OXT(5020) , OXTR(5021) ; rat ... Oxtr(25342)

Description

Amino Acid Sequence

Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 [Disulfide Bridge: 1-6]

General description

Oxytocin (OXT) is a potent natriuretic hormone encoded by the gene mapped to human chromosome 20p13. It is synthesized along with its carrier protein neurophysin I from its inactive precursor prepro-OXT. OXT gene consists of three exons and two introns where first exon codes for hormone OXT while other exon codes for neurophysin I.

Application

Oxytocin has been used in immunocytochemistry analysis and it has also been used to study the mechanism responsible for the reduced ability of mice deficient in plasminogen (Plg) to support a litter during lactation.

Biochem/physiol Actions

Oxytocin (OXT) and arginine vasopressin hormone plays a vital role in regulation of water excretion, parturition and lactation. OXT has been implicated in hydromineral homeostasis and vascular and cardiac relaxation. Oxytocin might function as an effective therapeutic for psychiatric diseases, including depression, schizophrenia, anxiety disorders and autism. OXT has a potential as a marker of autism severity. OXT is an anorexigenic neuropeptide, which is implicated in social cognition and obsessive-compulsive behavior. Plasma oxytocin levels are high in children with Prader-willi syndrome (PWS) compared with unrelated and unaffected siblings. Deficiency of OXT hormone might contribute to pathogenesis of attention deficit/hyperactivity disorder (ADHD).

Stimulates uterine contraction and lactation; increases Na⁺ excretion; stimulates myometrial GTPase and phospholipase C.

Physical form

Lyophilized powder containing 3% oxytocin with mannitol and buffer salts.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable